Neonatal meningitis: Mortality, cerebrospinal fluid, and microbiological findings

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dc.contributor.authorNel E.
dc.date.accessioned2011-05-15T16:17:13Z
dc.date.available2011-05-15T16:17:13Z
dc.date.issued2000
dc.description.abstractThis study describes the bacteriology, cerebrospinal fluid (CSF) findings, and mortality of neonatal meningitis over an 11-year period. The minimum incidence of neonatal meningitis at Tygerberg Hospital is 0.72/1000 live births/year. Eighty-eight patients were included in the study. Median birthweight and age at diagnosis were 2320g and 12 days, respectively. CSF culture was positive in 77 (88 per cent), blood culture was positive in 51 (57 per cent), and Gram stain was positive in 58 (66 per cent). The most frequently cultured organisms were Group B Streptococcus, Klebsiella pneumoniae, and E. coli. Thirty (34 per cent) patients died, the majority within 72h after admission. The death rate was significantly increased in babies with a birthweight of less than 1 1500g (59 per cent). Increased total CSF protein was associated with an increased risk of death. Normal CSF cell count, total CSF protein and CSF glucose were found in six infants.
dc.description.versionArticle
dc.identifier.citationJournal of Tropical Pediatrics
dc.identifier.citation46
dc.identifier.citation4
dc.identifier.issn01426338
dc.identifier.urihttp://hdl.handle.net/10019.1/14120
dc.subjectglucose
dc.subjectprotein
dc.subjectage
dc.subjectarticle
dc.subjectbacterial meningitis
dc.subjectbacteriology
dc.subjectbirth weight
dc.subjectblood culture
dc.subjectcerebrospinal fluid
dc.subjectcerebrospinal fluid culture
dc.subjectcerebrospinal fluid cytology
dc.subjectcerebrospinal fluid examination
dc.subjectEscherichia coli
dc.subjectfemale
dc.subjectGram staining
dc.subjecthospital
dc.subjecthospital admission
dc.subjecthuman
dc.subjectincidence
dc.subjectKlebsiella pneumoniae
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnewborn
dc.subjectnewborn mortality
dc.subjectprotein cerebrospinal fluid level
dc.subjectSouth Africa
dc.subjectStreptococcus agalactiae
dc.subjectAge Factors
dc.subjectEscherichia coli
dc.subjectEscherichia coli Infections
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectKlebsiella Infections
dc.subjectKlebsiella pneumoniae
dc.subjectMeningitis, Bacterial
dc.subjectRisk Factors
dc.subjectSouth Africa
dc.titleNeonatal meningitis: Mortality, cerebrospinal fluid, and microbiological findings
dc.typeArticle
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