Opsoclonus-myoclonus in an HIV-infected child on antiretroviral therapy-possible immune reconstitution inflammatory syndrome

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dc.contributor.authorvan Toorn R.
dc.contributor.authorRabie H.
dc.contributor.authorWarwick, James M.en_ZA
dc.date.accessioned2011-05-15T16:16:22Z
dc.date.available2011-05-15T16:16:22Z
dc.date.issued2005
dc.description.abstractThe exact immunopathogenesis and neuroanatomical localization of opsoclonus-myoclonus ataxia syndrome remains unclear. We describe a 1 year 9 month old girl who, shortly after commencement of highly active antiretroviral therapy developed opsoclonus-myoclonus syndrome and subsequently died of disseminated cytomegalovirus infection. We postulate on the etiological factors that may have played a role in the disease pathogenesis of the patient's opsoclonus-myoclonus ataxia. Immune reconstitution inflammatory syndrome was considered the most likely because of the initial CD4 depletion and the onset of symptoms shortly after initiation of antiretroviral therapy. Single photon emission computed tomography (SPECT) proved helpful by localizing the area of dysfunction to the cerebellar vermis. © 2005 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationEuropean Journal of Paediatric Neurology
dc.identifier.citation9
dc.identifier.citation6
dc.identifier.issn10903798
dc.identifier.other10.1016/j.ejpn.2005.06.007
dc.identifier.urihttp://hdl.handle.net/10019.1/13751
dc.subjectantiretrovirus agent
dc.subjectCD4 antigen
dc.subjectcorticotropin
dc.subjectganciclovir
dc.subjecthexamethylpropylene amine oxime technetium tc 99m
dc.subjectimmunoglobulin
dc.subjectlamivudine
dc.subjectlopinavir plus ritonavir
dc.subjectstavudine
dc.subjectarticle
dc.subjectataxia
dc.subjectcase report
dc.subjectcause of death
dc.subjectcerebellum vermis
dc.subjectcytomegalovirus infection
dc.subjectfemale
dc.subjecthelper cell
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjectimmunopathogenesis
dc.subjectimmunopathology
dc.subjectinflammation
dc.subjectlymphocyte depletion
dc.subjectmyoclonus
dc.subjectneuroanatomy
dc.subjectopsoclonus
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectsingle photon emission computer tomography
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnti-Inflammatory Agents
dc.subjectAntiretroviral Therapy, Highly Active
dc.subjectCD4 Lymphocyte Count
dc.subjectElectroencephalography
dc.subjectFatal Outcome
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectInfant
dc.subjectInflammation
dc.subjectParaneoplastic Syndromes, Nervous System
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectTomography, X-Ray Computed
dc.titleOpsoclonus-myoclonus in an HIV-infected child on antiretroviral therapy-possible immune reconstitution inflammatory syndrome
dc.typeArticle
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