4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects

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dc.contributor.authorHussain, Hidayaten_ZA
dc.contributor.authorAli, Iftikharen_ZA
dc.contributor.authorWang, Daijieen_ZA
dc.contributor.authorMamadalieva, Nilufar Z.en_ZA
dc.contributor.authorHussain, Wahiden_ZA
dc.contributor.authorCsuk, Reneen_ZA
dc.contributor.authorLoesche, Anneen_ZA
dc.contributor.authorFischer, Lucieen_ZA
dc.contributor.authorStaerk, Danen_ZA
dc.contributor.authorAnam, Syarifulen_ZA
dc.contributor.authorAlZain, Mashail N.en_ZA
dc.contributor.authorMushtaq, Mariaen_ZA
dc.contributor.authorUl-Haq, Zaheeren_ZA
dc.contributor.authorUllah, Riazen_ZA
dc.contributor.authorNoman, Omar M.en_ZA
dc.contributor.authorAbbas, Ghulamen_ZA
dc.contributor.authorGreen, Ivan R.en_ZA
dc.date.accessioned2021-04-01T06:37:07Z
dc.date.available2021-04-01T06:37:07Z
dc.date.issued2020-11-17
dc.descriptionCITATION: Hussain, H. et al. 2020. 4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects, Biomolecules, 10(11):1562, doi:10.3390/biom10111562.
dc.descriptionThe original publication is available at https://www.mdpi.com
dc.description.abstractENGLISH ABSTRACT: Ranunculus muricatus L. is a spiny fruit buttercup that is used in various traditional medicinal systems. In the current investigation of R. muricatus, the new chalcone 4-benzyloxylonchocarpin (1), the new anthraquinone muracatanes A (2), the new-to-nature anthraquinone muracatanes B (3), and the new naphthalene analog muracatanes C (4) were isolated, in addition to the three previously reported compounds, 4-methoxylonchocarpin (5), β-sitosterol (6), and β-sitosterol β-D-glucopyranoside (7). Their structures were elucidated using 1D (1H and 13C) and 2D (COSY, HSQC, and HMBC) NMR spectroscopy and HR-ESI-MS. Chalcone 1 showed potent acetylcholinesterase inhibitory effects with Ki of 5.39 µM and Ki′ of 3.54 µM, but none of the isolated compounds showed inhibitory activity towards butyrylcholinesterase. Anthraquinone 3 illustrated α-glucosidase inhibitory effects with IC50-values of 164.46 ± 83.04 µM. Compound 5 displayed moderate cytotoxic activity towards ovarian carcinoma (A2780, IC50 = 25.4 µM), colorectal adenocarcinoma (HT29, IC50 = 20.2 µM), breast cancer (MCF7, IC50 = 23.7 µM), and thyroid carcinoma (SW1736, IC50 = 26.2 µM) while it was inactive towards pharynx carcinoma (FaDu: IC50 > 30 µM).en_ZA
dc.description.sponsorshipDeanship of Scientific Research at Princess Nourah Bint Abdulrahman University
dc.description.sponsorshipIndonesia Endowment Fund for Education
dc.description.urihttps://www.mdpi.com/2218-273X/10/11/1562
dc.description.versionPublisher's version
dc.format.extent17 pagesen_ZA
dc.identifier.citationHussain, H. et al. 2020. 4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects, Biomolecules, 10(11):1562, doi:10.3390/biom10111562.en_ZA
dc.identifier.issn2218-273X (online)
dc.identifier.otherdoi:10.3390/biom10111562
dc.identifier.urihttp://hdl.handle.net/10019.1/109734
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectRanunculus muricatusen_ZA
dc.subjectAcetylcholinesteraseen_ZA
dc.subjectGlucosidasesen_ZA
dc.title4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effectsen_ZA
dc.typeArticleen_ZA
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