Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock

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dc.contributor.advisorOuifki, Rachiden_ZA
dc.contributor.advisorKajunguri, Damianen_ZA
dc.contributor.advisorVale, Glyn A.en_ZA
dc.contributor.advisorTorr, Stephen J.en_ZA
dc.contributor.authorHargrove, John W.en_ZA
dc.date.accessioned2013-02-21T13:45:13Z
dc.date.available2013-02-21T13:45:13Z
dc.date.issued2012-05
dc.descriptionCITATION: Ouifki, R., et al. 2012. Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock. PLoS Neglected Tropical Diseases, 6(5): 1-10, doi: 10.1371/journal.pntd.0001615.
dc.descriptionThe original publication is available at http://journals.plos.org/plosntds
dc.description.abstractAbstract Background: In Uganda, Rhodesian sleeping sickness, caused by Trypanosoma brucei rhodesiense, and animal trypanosomiasis caused by T. vivax and T. congolense, are being controlled by treating cattle with trypanocides and/or insecticides. We used a mathematical model to identify treatment coverages required to break transmission when host populations consisted of various proportions of wild and domestic mammals, and reptiles. Methodology/Principal Findings: An Ro model for trypanosomiasis was generalized to allow tsetse to feed off multiple host species. Assuming populations of cattle and humans only, pre-intervention Ro values for T. vivax, T. congolense, and T. brucei were 388, 64 and 3, respectively. Treating cattle with trypanocides reduced R0 for T. brucei to ,1 if .65% of cattle were treated, vs 100% coverage necessary for T. vivax and T. congolense. The presence of wild mammalian hosts increased the coverage required and made control of T. vivax and T. congolense impossible. When tsetse fed only on cattle or humans, R0 for T. brucei was ,1 if 20% of cattle were treated with insecticide, compared to 55% for T. congolense. If wild mammalian hosts were also present, control of the two species was impossible if proportions of non-human bloodmeals from cattle were ,40% or ,70%, respectively. R0 was ,1 for T. vivax only when insecticide treatment led to reductions in the tsetse population. Under such circumstances R0,1 for T. brucei and T. congolense if cattle make up 30% and 55%, respectively of the non-human tsetse bloodmeals, as long as all cattle are treated with insecticide. Conclusions/Significance: In settled areas of Uganda with few wild hosts, control of Rhodesian sleeping sickness is likely to be much more effectively controlled by treating cattle with insecticide than with trypanocides.en_ZA
dc.description.sponsorshipEuropean Union's Seventh Framework Programme (FP7/2007-2013); grant agreement no. 221948 (ICONZ). SACEMA funding: Dept of Science and Technology, Government of South Africa. Financial support: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) and DRD Research into Use Programme.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent10 pagesen_ZA
dc.identifier.citationOuifki, R., et al. 2012. Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock. PLoS Neglected Tropical Diseases, 6(5): 1-10, doi: 10.1371/journal.pntd.0001615
dc.identifier.issn1935-2735 (online)
dc.identifier.issn1935-2727 (print)
dc.identifier.otherdoi: 10.1371/journal.pntd.0001615
dc.identifier.urihttp://hdl.handle.net/10019.1/79593
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTrypanosoma brucei rhodesienseen_ZA
dc.subjectAfrican trypanosomiasisen_ZA
dc.subjectAnimal trypanosomiasisen_ZA
dc.subjectT. vivaxen_ZA
dc.subjectT. congolenseen_ZA
dc.subjectTrypanocidesen_ZA
dc.subjectInsecticidesen_ZA
dc.subjectRhodesian sleeping sicknessen_ZA
dc.subjectTsetse-fliesen_ZA
dc.titleModeling the control of trypanosomiasis using trypanocides or insecticide-treated livestocken_ZA
dc.typeArticleen_ZA
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