Impact of HIV co-infection on plasma level of cytokines and chemokines of pulmonary tuberculosis patients

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dc.contributor.authorMihret, Adaneen_ZA
dc.contributor.authorAbebe, Markosen_ZA
dc.contributor.authorBekele, Yonasen_ZA
dc.contributor.authorAseffa, Abrahamen_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorHowe, Rawleighen_ZA
dc.date.accessioned2014-09-17T08:16:13Z
dc.date.available2014-09-17T08:16:13Z
dc.date.issued2014-03-04
dc.date.updated2014-04-03T07:47:28Z
dc.descriptionCITATION: Mihret, A. et al. 2014. Impact of HIV co-infection on plasma level of cytokines and chemokines of pulmonary tuberculosis patients. BMC Infectious Diseases, 14:125, doi:10.1186/1471-2334-14-125.en_ZA
dc.descriptionThe original publication is available at http://www.biomedcentral.com/1471-2334/14/125en_ZA
dc.description.abstractBackground The immunologic environment during HIV/M. tuberculosis co-infection is characterized by cytokine and chemokine irregularities that have been shown to increase immune activation, viral replication, and T cell dysfunction. Methods We analysed ex vivo plasma samples from 17 HIV negative and 16 HIV pulmonary tuberculosis co infected cases using Luminex assay to see impact of HIV co-infection on plasma level of cytokines and chemokines of pulmonary tuberculosis patients before and after anti Tuberculosis treatment. Results The median plasma level of IFN-γ, IL-4, MCP-3, MIP-1β and IP-10 was significantly different (P < 0.05) before and after treatment in HIV negative TB patients but not in HIV positive TB patients. There was no significant difference between HIV positive and HIV negative TB patients (P > 0.05) in the plasma level of any of the cytokines or chemokines before treatment and anti TB treatment did not change the level of any of the measured cytokines in HIV positive tuberculosis patients. The ratio of IFN-γ/IL-10 and IFN-γ/IL-4 showed a significant increase after treatment in HIV negative TB cases but not in HIV positive TB cases which might indicate prolonged impairment of immune response to TB in HIV positive TB patients as compared to HIV negative tuberculosis patients. Conclusions HIV positive and HIV negative Tuberculosis patients display similar plasma cytokine and chemokine pattern. However, anti TB treatment significantly improves the Th1 cytokines and level of chemokines but does not restore the immune response in HIV positive individuals.en_ZA
dc.description.versionPublishers' versionen_ZA
dc.identifier.citationMihret, A. et al. 2014. Impact of HIV co-infection on plasma level of cytokines and chemokines of pulmonary tuberculosis patients. BMC Infectious Diseases, 14:125, doi:10.1186/1471-2334-14-125.en_ZA
dc.identifier.issn1471-2334 (online)
dc.identifier.otherdoi:10.1186/1471-2334-14-125en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/95575
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderAdane Mihret et al.; licensee BioMed Central Ltd.en_ZA
dc.subjectTuberculosis -- Immunological aspectsen_ZA
dc.subjectHIV infections -- Immunological aspectsen_ZA
dc.subjectChemokine -- Immunological aspectsen_ZA
dc.subjectCytokines -- Immunological aspectsen_ZA
dc.titleImpact of HIV co-infection on plasma level of cytokines and chemokines of pulmonary tuberculosis patientsen_ZA
dc.typeArticleen_ZA
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