Dihydralazine or ketanserin for severe hypertension in pregnancy? Preliminary results

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dc.contributor.authorSteyn D.W.
dc.contributor.authorOdendaal H.J.
dc.date.accessioned2011-05-15T16:16:22Z
dc.date.available2011-05-15T16:16:22Z
dc.date.issued1997
dc.description.abstractObjective: To compare the efficacy and safety of intravenous dihydralazine with ketanserin in the management of severe hypertension in the third trimester. Study design: A double blind randomised controlled trial, comparing 5 mg dihydralazine with 10 mg ketanserin after an intravenous infusion of 500 ml of a crystalloid solution. Medication was repeated every 20 min till the therapeutic goal of 90 mm Hg was reached, to a maximum of 4 dosages. Main outcome measures were treatment failures and emergency deliveries for fetal distress. Results: The therapeutic goal was met more often in patients receiving dihydralazine (36/38 compared to 27/42; P<0.01). The need for delivery for fetal distress did not differ (3 after dihydralazine, 1 after ketanserin, P=0.29). No therapy related perinatal loss occurred, but one mother with an undiagnosed phaechromocytoma died 24 h after receiving dihydralazine. Conclusion: Ketanserin in this dosage is less effective to lower diastolic blood pressure. The place of a fluid load prior to dihydralazine needs to be further investigated, as fetal heart rate decelerations were less common-than previously reported.
dc.description.versionArticle
dc.identifier.citationEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.identifier.citation75
dc.identifier.citation2
dc.identifier.issn03012115
dc.identifier.other10.1016/S0301-2115(97)00123-1
dc.identifier.urihttp://hdl.handle.net/10019.1/13748
dc.subjectdihydralazine
dc.subjectketanserin
dc.subjectadult
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled study
dc.subjectcrystalloid
dc.subjectdouble blind procedure
dc.subjectdrug efficacy
dc.subjectdrug safety
dc.subjectdrug screening
dc.subjectfemale
dc.subjectfetus distress
dc.subjecthuman
dc.subjectintravenous drug administration
dc.subjectmajor clinical study
dc.subjectmaternal hypertension
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectthird trimester pregnancy
dc.subjecttreatment outcome
dc.subjectAdult
dc.subjectAntihypertensive Agents
dc.subjectBlood Pressure
dc.subjectDihydralazine
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectFetal Death
dc.subjectFetal Distress
dc.subjectHeart Rate, Fetal
dc.subjectHumans
dc.subjectHypertension
dc.subjectInfusions, Intravenous
dc.subjectKetanserin
dc.subjectPregnancy
dc.subjectPregnancy Complications, Cardiovascular
dc.titleDihydralazine or ketanserin for severe hypertension in pregnancy? Preliminary results
dc.typeArticle
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