Descriptive study evaluating the management and outcome of infants aged 21-90 days presenting to a paediatric emergency department with a possible serious bacterial infection

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dc.contributor.advisorRedfern, Andrewen_ZA
dc.contributor.advisorSmit, Liezlen_ZA
dc.contributor.authorLishman, Juanitaen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health.en_ZA
dc.date.accessioned2019-11-26T09:31:54Z
dc.date.accessioned2019-12-11T06:39:56Z
dc.date.available2021-02-01T03:00:08Z
dc.date.issued2019-12
dc.descriptionThesis (MMed)--Stellenbosch University, 2019.en_ZA
dc.description.abstractBackground: Young infants with a possible serious bacterial infection (SBI) are a common presentation to paediatric emergency departments (PEDs). It is often difficult to distinguish clinically between self-limiting viral infections and a SBI. Available evaluation algorithms to assist clinicians are mostly from high income countries. Data to inform clinical practice in low and middle income countries are lacking. Objectives: To determine the period prevalence of SBI and invasive bacterial infection (IBI) and describe current practice in the assessment and management of young infants aged 21-90 days presenting with a possible SBI to a PED in Cape Town, South Africa. Methods: A retrospective cross-sectional review of infants 21-90 days old presenting to the Tygerberg Hospital PED between 1 January 2016 to 31 May 2016. Results: A total of 248 infants 21-90 days were included in the study. Sixty-two patients (25%, 95% CI 20-30) had a SBI and 13 (5.2%, 95% CI 3-8) had an IBI. One hundred and sixty five infants had a possible SBI based on IMCI criteria. The sensitivity of the IMCI criteria in detecting SBI was 82.3% (95% CI 70.5-90.8) and the specificity 38.7% (95% CI 31.7-46.1). More than half (51.2%) of the infants received antibiotics within the 48 hours prior to presentation, of which 33.5% included intramuscular injection of Ceftriaxone. Only 20 (8.0%) patients in this age group were discharged home after initial evaluation. Of the infants who did not have a SBI, 96 (51.9%) received intravenous antibiotics. Conclusion: Period prevalence of SBI and IBI was much higher compared to that published in the literature. Evaluation algorithms to stratify risk of SBI are needed to assist clinicians in diagnosing and managing infants appropriately in low and middle income settings.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.versionMastersen_ZA
dc.embargo.terms2020-12-31
dc.identifier.urihttp://hdl.handle.net/10019.1/106946
dc.language.isoen_ZAen_ZA
dc.subjectInfantsen_ZA
dc.subjectPaediatricen_ZA
dc.subjectBacterial infectionen_ZA
dc.subjectCommunicable diseasesen_ZA
dc.titleDescriptive study evaluating the management and outcome of infants aged 21-90 days presenting to a paediatric emergency department with a possible serious bacterial infectionen_ZA
dc.typeThesisen_ZA
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