Hyperglycaemia in critically ill patients : the immune system’s sweet tooth

Simple item page
dc.contributor.authorVan Niekerk, Gustaven_ZA
dc.contributor.authorDavis, Tanja Andreaen_ZA
dc.contributor.authorEngelbrecht, Anna-Marten_ZA
dc.date.accessioned2017-08-07T05:53:42Z
dc.date.available2017-08-07T05:53:42Z
dc.date.issued2017
dc.date.updated2017-08-06T03:33:45Z
dc.descriptionCITATION: Van Niekerk, G., Davis, T. & Engelbrecht, A.-M. 2017. Hyperglycaemia in critically ill patients : the immune system’s sweet tooth. Critical Care, 21:202, doi:10.1186/s13054-017-1775-1.en_ZA
dc.descriptionThe original publication is available at https://ccforum.biomedcentral.comen_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.description.abstractThere is an ongoing debate regarding the efficacy of glycaemic control in critically ill patients. Here we briefly highlight the key function of elevated glucose in critically ill patients, namely, to enable elevation of aerobic glycolysis in rapidly dividing cells. In particular, aerobic glycolysis provides metabolic intermediates necessary for expansion of biomass in immune cells and promotion of tissue repair. Furthermore, we emphasise that insulin may inhibit autophagy, a cell survival process used in the bulk degradation of cellular debris and damaged organelles. These observations provide a rational basis for tolerating elevated glucose levels in certain critically ill patients.en_ZA
dc.description.urihttps://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1775-1
dc.description.versionPublisher's versionen_ZA
dc.format.extent5 pages : illustrationsen_ZA
dc.identifier.citationVan Niekerk, G., Davis, T. & Engelbrecht, A.-M. 2017. Hyperglycaemia in critically ill patients : the immune system’s sweet tooth. Critical Care, 21:202, doi:10.1186/s13054-017-1775-1.en_ZA
dc.identifier.isbn1364-8535
dc.identifier.issn1466-609X
dc.identifier.otherdoi:10.1186/s13054-017-1775-1
dc.identifier.urihttp://hdl.handle.net/10019.1/102057
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHyperglycaemiaen_ZA
dc.subjectGlycaemic controlen_ZA
dc.subjectDiabetes -- Treatmenten_ZA
dc.subjectAutophagyen_ZA
dc.titleHyperglycaemia in critically ill patients : the immune system’s sweet toothen_ZA
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
vanniekerk_hyperglycaemia_2017.pdf
Size:
454.54 KB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.95 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Physiological Sciences)