Spatial heterogeneity in projected leprosy trends in India

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dc.contributor.authorBrook, Cara E.en_ZA
dc.contributor.authorBeauclair, Roxanneen_ZA
dc.contributor.authorNgwenya, Olinaen_ZA
dc.contributor.authorWorden, Leeen_ZA
dc.contributor.authorNdeffo-Mbah, Martialen_ZA
dc.contributor.authorLietman, Thomas M.en_ZA
dc.contributor.authorSatpathy, Sudhir K.en_ZA
dc.contributor.authorGalvani, Alison P.en_ZA
dc.contributor.authorPorco, Travis C.en_ZA
dc.date.accessioned2016-08-30T11:58:04Z
dc.date.available2016-08-30T11:58:04Z
dc.date.issued2015-10-22
dc.descriptionCITATION: Brook, C. E. et al. 2015. Spatial heterogeneity in projected leprosy trends in India. Parasites & Vectors, 8:542, doi:10.1186/s13071-015-1124-7.
dc.descriptionThe original publication is available at http://parasitesandvectors.biomedcentral.com
dc.description.abstractBackground: Leprosy is caused by infection with Mycobacterium leprae and is characterized by peripheral nerve damage and skin lesions. The disease is classified into paucibacillary (PB) and multibacillary (MB) leprosy. The 2012 London Declaration formulated the following targets for leprosy control: (1) global interruption of transmission or elimination by 2020, and (2) reduction of grade-2 disabilities in newly detected cases to below 1 per million population at a global level by 2020. Leprosy is treatable, but diagnosis, access to treatment and treatment adherence (all necessary to curtail transmission) represent major challenges. Globally, new case detection rates for leprosy have remained fairly stable in the past decade, with India responsible for more than half of cases reported annually. Methods: We analyzed publicly available data from the Indian Ministry of Health and Family Welfare, and fit linear mixed-effects regression models to leprosy case detection trends reported at the district level. We assessed correlation of the new district-level case detection rate for leprosy with several state-level regressors: TB incidence, BCG coverage, fraction of cases exhibiting grade 2 disability at diagnosis, fraction of cases in children, and fraction multibacillary. Results: Our analyses suggest an endemic disease in very slow decline, with substantial spatial heterogeneity at both district and state levels. Enhanced active case finding was associated with a higher case detection rate. Conclusions: Trend analysis of reported new detection rates from India does not support a thesis of rapid progress in leprosy control.en_ZA
dc.description.urihttp://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-1124-7
dc.description.versionPublisher's version
dc.format.extent11 pages
dc.identifier.citationBrook, C. E. et al. 2015. Spatial heterogeneity in projected leprosy trends in India. Parasites & Vectors, 8:542, doi:10.1186/s13071-015-1124-7.
dc.identifier.issn1756-3305 (online)
dc.identifier.otherdoi:10.1186/s13071-015-1124-7
dc.identifier.urihttp://hdl.handle.net/10019.1/99510
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subjectLeprosy -- Indiaen_ZA
dc.subjectMycobacterium lepraeen_ZA
dc.titleSpatial heterogeneity in projected leprosy trends in Indiaen_ZA
dc.typeArticleen_ZA
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