Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics

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dc.contributor.authorCaschera, Alexanderen_ZA
dc.contributor.authorMistry, Kamlesh B.en_ZA
dc.contributor.authorBedard, Josephen_ZA
dc.contributor.authorRonan, Evanen_ZA
dc.contributor.authorSyed, Moiz A.en_ZA
dc.contributor.authorKhan, Aman U.en_ZA
dc.contributor.authorLough, Alan J.en_ZA
dc.contributor.authorWolfaardt, Gideonen_ZA
dc.contributor.authorFoucher, Daniel A.en_ZA
dc.date.accessioned2021-09-22T06:47:38Z
dc.date.available2021-09-22T06:47:38Z
dc.date.issued2019
dc.descriptionCITATION: Caschera, A., et al. 2019. Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics. RSC Advances, 9(6):3140-3150, doi:10.1039/C8RA10173F.
dc.descriptionThe original publication is available at https://pubs.rsc.org/en/journals/journalissues/ra#!subjects
dc.description.abstractWith the risks associated with healthcare-associated infections and the rise of antibiotic resistant microorganisms, there is an important need to control the proliferation of these factors in hospitals, retirement homes and other institutions. This work explores the development and application of a novel class of sulfonamide-based quaternary ammonium antimicrobial coatings, anchored to commercially and clinically relevant material surfaces. Synthesized in high yields (60–97%), benzophenone-anchored antimicrobials were spray-coated and UV grafted onto plastic surfaces, while silane-anchored variants were adhered to select textiles via dip-coating. Surface modified samples were characterised by advancing contact angle, anionic dye staining, X-ray photoelectron spectroscopy and atomic force microscopy. After verifying coating quality through the above characterization methods, microbiological testing was performed on batch samples in conditions that simulate the natural inoculation of surfaces and objects (solid/air) and water containers (solid/liquid). Using the previously established Large Drop Inoculum (LDI) protocol at solid/air interfaces, all treated samples showed a full reduction (105–107 CFU) of viable Arthrobacter sp., S. aureus, and E. coli after 3 h of contact time. Additional testing of the walls of plastic LDPE vials treated with a UV-cured sulfonamide antimicrobial at a solid/liquid interface using the newly developed Large Reservoir Inoculum (LRI) protocol under static conditions revealed a complete kill (>106 reduction) of Gram-positive Arthrobacter sp., and a partial kill (>104 reduction) of Gram-negative E. coli within 24–48 h of contact.en_ZA
dc.description.urihttps://pubs.rsc.org/en/content/articlelanding/2019/RA/C8RA10173F
dc.description.versionPublisher's version
dc.format.extent11 pages
dc.identifier.citationCaschera, A., et al. 2019. Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics. RSC Advances, 9(6):3140-3150, doi:10.1039/C8RA10173F
dc.identifier.issn2046-2069 (online)
dc.identifier.otherdoi:10.1039/C8RA10173F
dc.identifier.urihttp://hdl.handle.net/10019.1/123067
dc.language.isoen_ZAen_ZA
dc.publisherRoyal Society of Chemistry
dc.rights.holderRoyal Society of Chemistry
dc.subjectAntimicrobialsen_ZA
dc.subjectSulfonamidesen_ZA
dc.subjectAnti-infective agentsen_ZA
dc.subjectQuarternary ammonium saltsen_ZA
dc.subjectCoatings -- Bacteriologyen_ZA
dc.subjectDisinfection and disinfectantsen_ZA
dc.titleSurface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plasticsen_ZA
dc.typeArticleen_ZA
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