Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection

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dc.contributor.authorRiou, Catherineen_ZA
dc.contributor.authorDu Bruyn, Elsaen_Za
dc.contributor.authorStek, Carien_ZA
dc.contributor.authorDaroowala, Remyen_ZA
dc.contributor.authorGoliath, Rene T.en_ZA
dc.contributor.authorAbrahams, Fatimaen_ZA
dc.contributor.authorSaid-Hartley, Qonitaen_ZA
dc.date.accessioned2023-03-27T09:20:49Zen_ZA
dc.date.available2023-03-27T09:20:49Zen_ZA
dc.date.issued2021-05en_ZA
dc.descriptionCITATION: Riou, C. et al. 2021. Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection. The Journal of Clinical Investigation 131(12):e149125. doi.10.1172/JCI149125.en_ZA
dc.descriptionThe original publication is available at: jci.orgen_ZA
dc.description.abstractT cells are involved in control of coronavirus disease 2019 (COVID-19), but limited knowledge is available on the relationship between antigen-specific T cell response and disease severity. Here, we used flow cytometry to assess the magnitude, function, and phenotype of SARS coronavirus 2–specific (SARS-CoV-2–specific) CD4+ T cells in 95 hospitalized COVID-19 patients, 38 of them being HIV-1 and/or tuberculosis (TB) coinfected, and 38 non–COVID-19 patients. We showed that SARSCoV- 2–specific CD4+ T cell attributes, rather than magnitude, were associated with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity, and enhanced HLA-DR expression. Moreover, HIV-1 and TB coinfection skewed the SARS-CoV-2 T cell response. HIV-1–mediated CD4+ T cell depletion associated with suboptimal T cell and humoral immune responses to SARS-CoV-2, and a decrease in the polyfunctional capacity of SARSCoV- 2–specific CD4+ T cells was observed in COVID-19 patients with active TB. Our results also revealed that COVID-19 patients displayed reduced frequency of Mycobacterium tuberculosis–specific CD4+ T cells, with possible implications for TB disease progression. These results corroborate the important role of SARS-CoV-2–specific T cells in COVID-19 pathogenesis and support the concept of altered T cell functions in patients with severe disease.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent16 pagesen_ZA
dc.identifier.citationRiou, C. et al. 2021. Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection. The Journal of Clinical Investigation 131(12):e149125. doi.10.1172/JCI149125.en_ZA
dc.identifier.issn0021-9738 (print)en_ZA
dc.identifier.issn1558-8238 (online)en_ZA
dc.identifier.otherdoi.10.1172/JCI149125en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126718en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society for Clinical Investigationen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectCOVID-19 (Disease)en_ZA
dc.subjectImmune response -- Molecular aspectsen_ZA
dc.subjectCellular immune responseen_ZA
dc.subjectT cells -- Receptorsen_ZA
dc.subjectCommunicable diseasesen_ZA
dc.subjectUCTDen_ZA
dc.titleRelationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfectionen_ZA
dc.typeArticleen_ZA
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