Detection of transmission clusters of HIV-1 subtype C over a 21-year period in Cape Town, South Africa

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dc.contributor.authorWilkinson, Eduanen_ZA
dc.contributor.authorEngelbrecht, Susanen_ZA
dc.contributor.authorDe Oliveira, Tulioen_ZA
dc.date.accessioned2016-03-03T09:22:47Z
dc.date.available2016-03-03T09:22:47Z
dc.date.issued2014-10-30
dc.descriptionPlease cite as follows: Wilkinson, E., Engelbrecht, S. & De Oliveira, T. 2014. Detection of transmission clusters of HIV-1 subtype C over a 21-year period in Cape Town, South Africa. PLoS ONE, 9(10):e109296, doi:10.1371/journal.pone.0109296.en_ZA
dc.descriptionThe original publication is available at http://journals.plos.org/plosoneen_ZA
dc.description.abstractIntroduction: Despite recent breakthroughs in the fight against the HIV/AIDS epidemic within South Africa, the transmission of the virus continues at alarmingly high rates. It is possible, with the use of phylogenetic methods, to uncover transmission events of HIV amongst local communities in order to identify factors that may contribute to the sustained transmission of the virus. The aim of this study was to uncover transmission events of HIV amongst the infected population of Cape Town. Methods and Results: We analysed gag p24 and RT-pol sequences which were generated from samples spanning over 21-years with advanced phylogenetic techniques. We identified two transmission clusters over a 21-year period amongst randomly sampled patients from Cape Town and the surrounding areas. We also estimated the origin of each of the identified transmission clusters with the oldest cluster dating back, on average, 30 years and the youngest dating back roughly 20 years. Discussion and Conclusion: These transmission clusters represent the first identified transmission events among the heterosexual population in Cape Town. By increasing the number of randomly sampled specimens within a dataset over time, it is possible to start to uncover transmission events of HIV amongst local communities in generalized epidemics. This information can be used to produce targeted interventions to decrease transmission of HIV in Africa.en_ZA
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109296
dc.description.versionPublisher's versionen_ZA
dc.format.extent11 pagesen_ZA
dc.format.extent11 pagesen_ZA
dc.identifier.citationWilkinson, E., Engelbrecht, S. & De Oliveira, T. 2014. Detection of transmission clusters of HIV-1 subtype C over a 21-year period in Cape Town, South Africa. PLoS ONE, 9(10):e109296, doi:10.1371/journal.pone.0109296.en_ZA
dc.identifier.issn1963-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0109296
dc.identifier.urihttp://hdl.handle.net/10019.1/98249
dc.language.isoen_ZAen_ZA
dc.publisherPLoSen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV (Viruses) -- Transmissionen_ZA
dc.subjectHIV infections -- Transmissionen_ZA
dc.titleDetection of transmission clusters of HIV-1 subtype C over a 21-year period in Cape Town, South Africaen_ZA
dc.typeArticleen_ZA
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