Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance

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dc.contributor.authorAuger, Daniel A.
dc.contributor.authorZhong, Xiaodong
dc.contributor.authorEpstein, Frederick H.
dc.contributor.authorSpottiswoode, Bruce S.
dc.date.accessioned2012-05-18T13:25:35Z
dc.date.available2012-05-18T13:25:35Z
dc.date.issued2012-01
dc.date.updated2012-03-23T12:18:24Z
dc.descriptionThe original publication is available at http://www.jcmr-online.com/content/14/1/4en_ZA
dc.description.abstractBackground The mechanics of the right ventricle (RV) are not well understood as studies of the RV have been limited. This is, in part, due to the RV's thin wall, asymmetric geometry and irregular motion. However, the RV plays an important role in cardiovascular function. This study aims to describe the complex mechanics of the healthy RV using three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR). Methods Whole heart 3D cine DENSE data were acquired from five healthy volunteers. Tailored post-processing algorithms for RV mid-wall tissue tracking and strain estimation are presented. A method for sub-dividing the RV into four regions according to anatomical land marks is proposed, and the temporal evolution of strain was assessed in these regions. Results The 3D cine DENSE tissue tracking methods successfully capture the motion and deformation of the RV at a high spatial resolution in all volunteers. The regional Lagrangian peak surface strain and time to peak values correspond with previous studies using myocardial tagging, DENSE and strain encoded CMR. The inflow region consistently displays lower peak strains than the apical and outflow regions, and the time to peak strains suggest RV mechanical activation in the following order: inflow, outflow, mid, then apex. Conclusions Model-free techniques have been developed to study the myocardial mechanics of the RV at a high spatial resolution using 3D cine DENSE CMR. The consistency of the regional RV strain patterns across healthy subjects is encouraging and the techniques may have clinical utility in assessing disrupted RV mechanics in the diseased heart.en_ZA
dc.description.versionPublishers' Versionen_ZA
dc.format.extent9 p. : ill.
dc.identifier.citationAuger, D. A., Zhong, X. Epstein, F. H. & Spottiswoode, B. S. 2012. Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 14(1), 4:1-9en_ZA
dc.identifier.issn1532-429X (online)
dc.identifier.issn1097-6647 (print)
dc.identifier.urihttp://dx.doi.org/10.1186/1532-429X-14-4
dc.identifier.urihttp://hdl.handle.net/10019.1/21138
dc.language.isoen_ZAen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.rights.holderAuger et al.; licensee BioMed Central Ltd.en_ZA
dc.subjectCardiovascular system -- Magnetic resonance imagingen_ZA
dc.subjectHeart -- Ventricles -- Magnetic resonance imagingen_ZA
dc.subjectDisplacement Encoding with Stimulated Echoes (DENSE)en_ZA
dc.titleMapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonanceen_ZA
dc.typeArticleen_ZA
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