Effect of semen characteristics on pregnancy rate in a gamete intrafallopian transfer program

Simple item page
dc.contributor.authorKruger T.F.
dc.contributor.authorFranken D.R.
dc.contributor.authorStander E.
dc.contributor.authorSwart Y.
dc.contributor.authorVan der Merwe J.P.
dc.date.accessioned2011-05-15T16:15:35Z
dc.date.available2011-05-15T16:15:35Z
dc.date.issued1993
dc.description.abstractThe aim of this study was to evaluate the influence of sperm morphology, swim-up concentration, and insemination volume on pregnancy outcome in patients undergoing gamete intrafallopian transfer (GIFT) treatment in whom the male partner had a morphology of less than 14%. Only patients who received four oocytes were entered into this study (n=103). In all cases the swim-up procedure time was standardized to 1 h and the insemination concentration was standardized to 500,000 per oviduct. There was no significant difference in pregnancy rate when normal morphology, swim-up concentration, or insemination volume were used as predictors. In the P pattern group (<4% normal forms) only four of the 28 (14%) patients had ongoing pregnancies, whereas in the G pattern group (5% to 14% normal forms) 16 out of 75 (21%) had ongoing pregnancies (P vs G, p > 0.05; not significant). The fertilization rate among excess oocytes in the p pattern group was 18% but was 39% (p < .0001) in the G pattern group. When an attempt was made to compensate for low morphology by increasing insemination concentration no significant difference in the pregnancy rate between the P and G pattern groups in the GIFT program was recorded. This was not the case when the in vitro fertilization rate was used as an endpoint. Insemination volume and swim-up concentration played no role in pregnancy rate.
dc.description.versionArticle
dc.identifier.citationArchives of Andrology
dc.identifier.citation31
dc.identifier.citation2
dc.identifier.issn01485016
dc.identifier.urihttp://hdl.handle.net/10019.1/13401
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgamete intrafallopian transfer
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectinfertility
dc.subjectmale
dc.subjectpregnancy rate
dc.subjectpriority journal
dc.subjectseminal plasma
dc.subjectspermatozoon count
dc.subjectspermatozoon motility
dc.subjectFemale
dc.subjectGamete Intrafallopian Transfer
dc.subjectHuman
dc.subjectMale
dc.subjectPregnancy
dc.subjectSemen
dc.subjectSperm Count
dc.titleEffect of semen characteristics on pregnancy rate in a gamete intrafallopian transfer program
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications