An investigation in the possible effect of chronic headache on neuropsychological function in aCL-negative patients with SLE

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dc.contributor.authorWhitelaw D.A.
dc.contributor.authorSpangenberg J.J.
dc.date.accessioned2011-05-15T16:17:19Z
dc.date.available2011-05-15T16:17:19Z
dc.date.issued2009
dc.description.abstractexists as to whether patients with migraine may suffer cortical damage. We investigate the possible association between impaired cognitive function and chronic headache in lupus patients. Sixty one patients with systemic lupus erythematosus but without the antiphospholipid (Hughes) syndrome were questioned about headaches and formally assessed for cognitive function. They were also subjected to magnetic resonance imaging (MRI). Twenty one patients denied any significant headaches, 19 reported migrainous headaches and 11 experienced an aura. Eleven patients experienced headaches with features of migraine but did not fulfill the criteria, and seven patients had tension headaches. All patients had stable lupus; there was no difference in the incidence of hypertension, age or previous episodes of neuropsychiatric lupus. Patients with migrainous headaches without aura had marginally shorter duration of disease. There was no difference between the groups with respect to eight different cognitive tests or the ventriculo brain index on MRI. We failed to detect cognitive impairment in lupus patients with chronic headaches including migrainous headaches. © 2009 SAGE Publications.
dc.description.versionArticle
dc.identifier.citationLupus
dc.identifier.citation18
dc.identifier.citation7
dc.identifier.issn09612033
dc.identifier.other10.1177/0961203308101282
dc.identifier.urihttp://hdl.handle.net/10019.1/14168
dc.subjectcardiolipin antibody
dc.subjectadult
dc.subjectantiphospholipid syndrome
dc.subjectarticle
dc.subjectchronic pain
dc.subjectcognitive defect
dc.subjectcontrolled study
dc.subjectdisease activity
dc.subjectdisease association
dc.subjectdisease control
dc.subjectdisease duration
dc.subjectheadache
dc.subjecthuman
dc.subjecthypertension
dc.subjectmajor clinical study
dc.subjectmigraine with aura
dc.subjectmigraine without aura
dc.subjectneuropsychological test
dc.subjectnuclear magnetic resonance imaging
dc.subjectpriority journal
dc.subjectsystemic lupus erythematosus
dc.subjecttension headache
dc.subjectAdult
dc.subjectAntibodies, Antiphospholipid
dc.subjectBrain
dc.subjectCase-Control Studies
dc.subjectCognition
dc.subjectHeadache Disorders
dc.subjectHumans
dc.subjectLupus Erythematosus, Systemic
dc.subjectMagnetic Resonance Imaging
dc.subjectMiddle Aged
dc.subjectMigraine Disorders
dc.subjectMigraine with Aura
dc.subjectNeuropsychological Tests
dc.titleAn investigation in the possible effect of chronic headache on neuropsychological function in aCL-negative patients with SLE
dc.typeArticle
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