The combination of red palm oil and rooibos show anti-inflammatory effects in rats

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dc.contributor.authorKatengua-Thamahane, Emmaen_ZA
dc.contributor.authorMarnewick, Jeanine L.en_ZA
dc.contributor.authorAjuwon, Olawale R.en_ZA
dc.contributor.authorChegou, Novel N.en_ZA
dc.contributor.authorSzucs, Gergoen_ZA
dc.contributor.authorFerdinandy, Peteren_ZA
dc.contributor.authorCsont, Tamasen_ZA
dc.contributor.authorCsonka, Csabaen_ZA
dc.contributor.authorVan Rooyen, Jacquesen_ZA
dc.date.accessioned2015-07-23T14:29:20Z
dc.date.available2015-07-23T14:29:20Z
dc.date.issued2014-12
dc.date.updated2015-01-16T20:04:36Z
dc.descriptionCITATION: Katengua-Thamahane, E. et al. 2014. The combination of red palm oil and rooibos show anti-inflammatory effects in rats. Journal of Inflammation, 11(1):41, doi:10.1186/s12950-014-0041-4.en_ZA
dc.descriptionThe original publication is available at http://www.journal-inflammation.com/content/11/1/41en_ZA
dc.description.abstractBackground Red palm oil (RPO) and rooibos have been shown to exhibit cardioprotective properties. RPO is rich in essential fatty acids and fat soluble antioxidants while rooibos contains polyphenolic compounds with a unique composition of flavonoids. They exert their biological effects in different cellular compartments. Therefore the combination of these two natural food compounds has the potential to enhance the spectrum of available dietary antioxidants in different cellular compartments, which could result in an enhanced protection against certain pathological conditions such as inflammation. Methods Male Wistar rats weighing 150-200 g were supplemented with RPO, rooibos or their combination for 28 days. The Langendorff system and the lipoposaccharide (LPS)-induced inflammatory model were used to establish if RPO and rooibos, when supplemented alone or in combination, will reverse the negative effects of LPS on cardiac function at baseline. The effect of dietary intervention was also investigated on modulation of pro-inflammatory and anti-inflammatory cytokines in plasma and myocardial tissue. Results and discussion The LPS resulted in induction of systemic inflammation as evidenced by increased levels of IL-1β in plasma of LPS-treated rats compared to their non-treated control counterparts. Dietary supplementation and LPS treatment did not have an effect on baseline cardiac functional parameters. However, the elevation of IL-1β levels in plasma of LPS-induced rats consuming either RPO or rooibos alone were paralleled with increased levels of the anti-inflammatory cytokine, IL-10. The combination of rooibos and RPO was associated with enhanced endogenous production of myocardial IL-10 in LPS-induced rats. Conclusion The results of this study indicate that RPO and rooibos when supplemented individually showed anti-inflammatory effect at systemic level while their combination exhibited an enhanced anti-inflammatory effect in the myocardial tissue. Therefore, the findings in the current study argue that the combination of these two natural food substances could be beneficial in clinically relevant conditions where inflammation plays a role.en_ZA
dc.description.versionPublishers’ versionen_ZA
dc.identifier.citationKatengua-Thamahane, E. et al. 2014. The combination of red palm oil and rooibos show anti-inflammatory effects in rats. Journal of Inflammation, 11(1):41, doi:10.1186/s12950-014-0041-4.en_ZA
dc.identifier.issn1476-9255 (online)
dc.identifier.otherdoi:10.1186/s12950-014-0041-4
dc.identifier.urihttp://hdl.handle.net/10019.1/97256
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderEmma Katengua-Thamahane et al.; licensee BioMed Central Ltd.
dc.subjectRed palm oil -- Health aspectsen_ZA
dc.subjectRooibos tea -- Health aspectsen_ZA
dc.subjectAnti-inflammatory agentsen_ZA
dc.subjectCardiotonic agentsen_ZA
dc.subjectAntioxidantsen_ZA
dc.subjectInflammationen_ZA
dc.titleThe combination of red palm oil and rooibos show anti-inflammatory effects in ratsen_ZA
dc.typeArticleen_ZA
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