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Identifying recent HIV infections : from serological assays to genomics

dc.contributor.authorMoyo, Sikhulileen_ZA
dc.contributor.authorWilkinson, Eduanen_ZA
dc.contributor.authorNovitsky, Vladimiren_ZA
dc.contributor.authorVandormael, Alainen_ZA
dc.contributor.authorGaseitsiwe, Simanien_ZA
dc.contributor.authorEssex, Maxen_ZA
dc.contributor.authorEngelbrecht, Susanen_ZA
dc.contributor.authorDe Oliveira, Tulioen_ZA
dc.date.accessioned2016-12-06T13:56:18Z
dc.date.available2016-12-06T13:56:18Z
dc.date.issued2015-10-23
dc.identifier.citationMoyo, S. et al. 2015. Identifying recent HIV infections : from serological assays to genomics. Viruses, 7(10):5508-5524, doi:10.3390/v7102887.
dc.identifier.issn1999-4915 (online)
dc.identifier.otherdoi:10.3390/v7102887
dc.identifier.urihttp://hdl.handle.net/10019.1/99945
dc.descriptionCITATION: Moyo, S. et al. 2015. Identifying recent HIV infections : from serological assays to genomics. Viruses, 7(10):5508-5524, doi:10.3390/v7102887.
dc.descriptionThe original publication is available at http://www.mdpi.com/journal/viruses
dc.description.abstractIn this paper, we review serological and molecular based methods to identify HIV infection recency. The accurate identification of recent HIV infection continues to be an important research area and has implications for HIV prevention and treatment interventions. Longitudinal cohorts that follow HIV negative individuals over time are the current gold standard approach, but they are logistically challenging, time consuming and an expensive enterprise. Methods that utilize cross-sectional testing and biomarker information have become an affordable alternative to the longitudinal approach. These methods use well-characterized biological makers to differentiate between recent and established HIV infections. However, recent results have identified a number of limitations in serological based assays that are sensitive to the variability in immune responses modulated by HIV subtypes, viral load and antiretroviral therapy. Molecular methods that explore the dynamics between the timing of infection and viral evolution are now emerging as a promising approach. The combination of serological and molecular methods may provide a good solution to identify recent HIV infection in cross-sectional data. As part of this review, we present the advantages and limitations of serological and molecular based methods and their potential complementary role for the identification of HIV infection recency.en_ZA
dc.description.urihttp://www.mdpi.com/1999-4915/7/10/2887
dc.format.extent17 pages
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.subjectHIV infectionsen_ZA
dc.subjectVirusesen_ZA
dc.subjectSerologyen_ZA
dc.subjectMolecular diagnosisen_ZA
dc.subjectGenomicsen_ZA
dc.titleIdentifying recent HIV infections : from serological assays to genomicsen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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