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History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region

dc.contributor.authorWilkinson, Eduanen_ZA
dc.contributor.authorEngelbrecht, Susanen_ZA
dc.contributor.authorDe Oliveira, Tulioen_ZA
dc.date.accessioned2016-11-24T10:09:31Z
dc.date.available2016-11-24T10:09:31Z
dc.date.issued2015-11-17
dc.identifier.citationWilkinson, E., Engelbrecht, S. & De Oliveira, T. 2015. History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region. Scientific Reports, 5:16897; doi: 10.1038/srep16897.
dc.identifier.issn2045-2322 (online)
dc.identifier.otherdoi: 10.1038/srep16897
dc.identifier.urihttp://hdl.handle.net/10019.1/99897
dc.descriptionCITATION: Wilkinson, E., Engelbrecht, S. & De Oliveira, T. 2015. History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region. Scientific Reports, 5:16897; doi: 10.1038/srep16897.
dc.descriptionThe original publication is available at http://www.nature.com/srep
dc.description.abstractHIV has spread at an alarming rate in South Africa, making it the country with the highest number of HIV infections. Several studies have investigated the histories of HIV-1 subtype C epidemics but none have done so in the context of social and political transformation in southern Africa. There is a need to understand how these processes affects epidemics, as socio-political transformation is a common and on-going process in Africa. Here, we genotyped strains from the start of the epidemic and applied phylodynamic techniques to determine the history of the southern Africa and South African epidemic from longitudinal sampled data. The southern African epidemic’s estimated dates of origin was placed around 1960 (95% HPD 1956–64), while dynamic reconstruction revealed strong growth during the 1970s and 80s. The South African epidemic has a similar origin, caused by multiple introductions from neighbouring countries, and grew exponentially during the 1980s and 90s, coinciding with socio-political changes in South Africa. These findings provide an indication as to when the epidemic started and how it has grown, while the inclusion of sequence data from the start of the epidemic provided better estimates. The epidemic have stabilized in recent years with the expansion of antiretroviral therapy.en_ZA
dc.description.urihttp://www.nature.com/articles/srep16897
dc.format.extent12 pages
dc.language.isoen_ZAen_ZA
dc.publisherNature
dc.subjectHIV (Viruses)en_ZA
dc.subjectHIV infections -- South Africaen_ZA
dc.titleHistory and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African regionen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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