Inactivated Proplex for the hemophiliac with inhibitors: A case report
Date
1979-06
Authors
Hesseling P.B.
Journal Title
Journal ISSN
Volume Title
Publisher
HMPG
Abstract
Inactivated prothrombin complex (Proplex) with a Kingdon time between 100 and 138 seconds effected functional recovery and adequate haemostasis in a haemophiliac with inhibitors of the high-responder type at comparatively low cost, and with no adverse effects. Home treatment was successful. Liver function remained normal during treatment. Statistically significant changes occurred in the prothrombin time (PT), fibrinogen levels and the thrombin time after each infusion. No evidence of diffuse intravascular coagulation (DIC) was ever detected. The inhibitor level decreased from 10 to 2 Bethesda units, and the radio-immunoassay (RIA) for Australia antigen remained negative.
Description
Article
The original publication is available at http://www.samj.org.za
The original publication is available at http://www.samj.org.za
Keywords
blood clotting factor VIII antibody, blood clotting factor IX complex, Prothrombin complex, Blood and hemopoietic system, Disseminated intravascular clotting, Liver function tests, Hemophilia --Treatment
Citation
Hesseling, P. B. 1979. Inactivated Proplex for the haemophiliac with inhibitors : a case study. South African Medical Journal,, 56: 108-110