Biological effect of asbestos dust on the peritoneal viscera of rats
CITATION: Engelbrecht, F.M. & Burger, B.F. 1973. Biological Effect of Asbestos Dust on the Peritoneal Viscera of Rats. S Afr Med J, 47(9):1746-1750.
The original publication is available at http://www.samj.org.za
ENGLISH ABSTRACT: Crocidolite and chrysotile asbestos suspensions were ip injected into rats. Peritoneal mesotheliomas were induced in 90% of the crocidolite group and in 30% of the chrysotile group. The pathology and possible pathogenesis are described and discussed. It is postulated that the asbestos fibers are encapsulated by fibrous tissue and that a soluble carcinogen then diffuses from these fibers to the mesothelial cells, causing anaplastic changes.