Biological effect of asbestos dust on the peritoneal viscera of rats

Engelbrecht, F. M. ; Burger, B. F. (1973-09)

CITATION: Engelbrecht, F.M. & Burger, B.F. 1973. Biological Effect of Asbestos Dust on the Peritoneal Viscera of Rats. S Afr Med J, 47(9):1746-1750.

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ENGLISH ABSTRACT: Crocidolite and chrysotile asbestos suspensions were ip injected into rats. Peritoneal mesotheliomas were induced in 90% of the crocidolite group and in 30% of the chrysotile group. The pathology and possible pathogenesis are described and discussed. It is postulated that the asbestos fibers are encapsulated by fibrous tissue and that a soluble carcinogen then diffuses from these fibers to the mesothelial cells, causing anaplastic changes.

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