Virological response without CD4 recovery. A case of disappearing soldiers - Can basic science help?
Date
2006
Authors
Madide A.
Rabie H.
Cotton M.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The objective of antiretroviral therapy (ART) is to suppress viral replication so that immune restoration can occur. Failure of immune restoration is usually associated with poor virological suppression. In children a good immunological and clinical response to ART is often achieved despite incomplete viral suppression. However, we have recently managed a number of children in whom immune restoration did not occur despite excellent virological suppression. We present a case, discuss possible causes and speculate on the appropriate course of action.
Description
Keywords
antibiotic agent, antiretrovirus agent, CD4 antigen, cotrimoxazole, efavirenz, lamivudine, oxygen, rifampicin, stavudine, tuberculostatic agent, virus RNA, anamnesis, article, atypical mycobacteriosis, body weight, bronchiectasis, case report, chest infection, clinical feature, disease classification, drug dose reduction, follow up, highly active antiretroviral therapy, hospital admission, human, Human immunodeficiency virus infection, laboratory test, lymphocyte count, male, patient compliance, preschool child, sputum smear, thorax radiography, treatment planning, tuberculin test, tuberculosis, virus load, world health organization
Citation
Southern African Journal of HIV Medicine
24
24