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Tuberculous meningitis-related optic neuritis: Recovery of vision with thalidomide in 4 consecutive cases

dc.contributor.authorSchoeman J.F.
dc.contributor.authorAndronikou S.
dc.contributor.authorStefan D.C.
dc.contributor.authorFreeman N.
dc.contributor.authorVan Toorn R.
dc.date.accessioned2011-05-15T16:16:53Z
dc.date.available2011-05-15T16:16:53Z
dc.date.issued2010
dc.identifier.citationJournal of Child Neurology
dc.identifier.citation25
dc.identifier.citation7
dc.identifier.issn08830738
dc.identifier.other10.1177/0883073809350507
dc.identifier.urihttp://hdl.handle.net/10019.1/13974
dc.description.abstractBlindness is an uncommon but devastating complication of tuberculosis meningitis. The main causes are chronically raised intracranial pressure (hydrocephalus and/or tuberculomas) or direct involvement of the optic chiasm or optic nerves by the basal arachnoiditis (inflammation and/or compression). Antituberculosis therapy combined with corticosteroids and control of intracranial pressure constitutes the mainstay of therapy for tuberculous meningitis. Despite these treatment measures, some patients develop blindness, mainly as a result of progressive optochiasmatic arachnoiditis. This led us to explore the role of adjuvant thalidomide therapy, and we describe the dramatic recovery of vision in 4 consecutive cases. Clinical recovery was accompanied by marked radiological improvement on magnetic resonance imaging (MRI) of the brain. © The Author(s) 2010.
dc.subjectacetylsalicylic acid
dc.subjectantibiotic agent
dc.subjectceftriaxone
dc.subjectethionamide
dc.subjectisoniazid
dc.subjectprednisone
dc.subjectpyrazinamide
dc.subjectrifampicin
dc.subjectthalidomide
dc.subjecttuberculostatic agent
dc.subjectabsence of side effects
dc.subjectacute lymphoblastic leukemia
dc.subjectadd on therapy
dc.subjectadjuvant therapy
dc.subjectarachnoiditis
dc.subjectarticle
dc.subjectbacterial meningitis
dc.subjectbone marrow biopsy
dc.subjectbrain
dc.subjectbrain infarction
dc.subjectbrain ventricle peritoneum shunt
dc.subjectcase report
dc.subjectcerebrospinal fluid cytology
dc.subjectchild
dc.subjectclinical examination
dc.subjectcomputer assisted tomography
dc.subjectconvalescence
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectdrug efficacy
dc.subjectelectroretinogram
dc.subjectenzyme linked immunosorbent assay
dc.subjecteye examination
dc.subjectfemale
dc.subjecthuman
dc.subjecthydrocephalus
dc.subjectlung tuberculosis
dc.subjectmale
dc.subjectmeningitis
dc.subjectmuscle stiffness
dc.subjectneuroimaging
dc.subjectnoncommunicating hydrocephalus
dc.subjectnuclear magnetic resonance imaging
dc.subjectnystagmus
dc.subjectoptic chiasm arachnoiditis
dc.subjectoptic neuritis
dc.subjectotorrhea
dc.subjectpapilledema
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectschool child
dc.subjectthorax radiography
dc.subjectthrombosis
dc.subjecttreatment duration
dc.subjecttreatment outcome
dc.subjecttuberculous meningitis
dc.subjectvision
dc.subjectvisual acuity
dc.subjectvisual impairment
dc.subjectAntitubercular Agents
dc.subjectBrain
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectOptic Neuritis
dc.subjectRecovery of Function
dc.subjectThalidomide
dc.subjectTreatment Outcome
dc.subjectTuberculosis, Meningeal
dc.subjectVision, Ocular
dc.titleTuberculous meningitis-related optic neuritis: Recovery of vision with thalidomide in 4 consecutive cases
dc.typeArticle
dc.description.versionArticle


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