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Diurnal blood pressure variation in the evaluation of early onset severe pre-eclampsia

dc.contributor.authorSteyn D.W.
dc.contributor.authorOdendaal H.J.
dc.contributor.authorHall D.R.
dc.date.accessioned2011-05-15T16:16:21Z
dc.date.available2011-05-15T16:16:21Z
dc.date.issued2008
dc.identifier.citationEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.identifier.citation138
dc.identifier.citation2
dc.identifier.issn03012115
dc.identifier.other10.1016/j.ejogrb.2007.08.010
dc.identifier.urihttp://hdl.handle.net/10019.1/13741
dc.description.abstractObjective: : To study the association between diurnal variation in blood pressure, the mean daily blood pressure and various complications of pregnancy in patients presenting with severe pre-eclampsia before 34 weeks' gestation. Study design: : Forty-four women presenting to a tertiary hospital in South Africa with severe pre-eclampsia between 28 and 34 weeks' gestation were managed expectantly for at least 8 days. We measured maternal blood pressure every 30 min with the pregnancy validated Spacelabs 90209 automated blood pressure monitor for 24 h periods on alternative days. The mean 24-h diastolic blood pressure measurement, the mean diastolic blood pressure for daytime and nighttime, the day-night blood pressure difference and the night-day ratio were compared with the occurrence of abruptio placentae, gestational age at delivery, neonatal intensive care unit admission, birth weight, abnormal umbilical artery Doppler FVW and reason for delivery. Results: : One hundred and seventy-six 24-h studies were analyzed. The day-night blood pressure difference decreased with increasing mean diastolic blood pressure (r = -0.323, p < 0.0001). A combination of normal mean diastolic blood pressure and normal day-night blood pressure difference was associated with increased gestational age and lower caesarean section rates. Conclusion: : The combination of mean diastolic blood pressure and day-night blood pressure difference may be a supplementary measurement of disease severity in early onset severe pre-eclampsia and seems to be of prognostic value. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.subjectmethyldopa
dc.subjectnifedipine
dc.subjectprazosin
dc.subjectadult
dc.subjectarticle
dc.subjectbirth weight
dc.subjectblood pressure measurement
dc.subjectblood pressure variability
dc.subjectcesarean section
dc.subjectcircadian rhythm
dc.subjectclinical article
dc.subjectdiagnostic value
dc.subjectdiastolic blood pressure
dc.subjectdisease course
dc.subjectdisease severity
dc.subjectDoppler flowmeter
dc.subjectDoppler flowmetry
dc.subjectearly diagnosis
dc.subjectfemale
dc.subjectfetus monitoring
dc.subjectgestation period
dc.subjectgestational age
dc.subjecthuman
dc.subjectinformed consent
dc.subjectmaternal age
dc.subjectmaternal hypertension
dc.subjectnewborn intensive care
dc.subjectparity
dc.subjectpatient monitoring
dc.subjectpreeclampsia
dc.subjectpregnancy complication
dc.subjectpregnant woman
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectsolutio placentae
dc.subjectSouth Africa
dc.subjecttertiary health care
dc.subjectAdult
dc.subjectBlood Pressure
dc.subjectBlood Pressure Monitoring, Ambulatory
dc.subjectCircadian Rhythm
dc.subjectFemale
dc.subjectHumans
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.titleDiurnal blood pressure variation in the evaluation of early onset severe pre-eclampsia
dc.typeArticle
dc.description.versionArticle


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