PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia
Date
2021-04
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The
burden of disease lies mainly in low-middle income countries. The aim of this project is to establish
a pre-eclampsia biobank in South Africa to facilitate research in the field of pre-eclampsia with a
focus on phenotyping severe disease.The approach of our biobank is to collect biological specimens,
detailed clinical data, tests, and biophysical examinations, including magnetic resonance imaging
(MRI) of the brain, MRI of the heart, transcranial Doppler, echocardiography, and cognitive function
tests.Women diagnosed with pre-eclampsia and normotensive controls are enrolled in the biobank
at admission to Tygerberg University Hospital (Cape Town, South Africa). Biological samples and
clinical data are collected at inclusion/delivery and during the hospital stay. Special investigations
as per above are performed in a subset of women. After two months, women are followed up
by telephonic interviews. This project aims to establish a biobank and database for severe organ
complications of pre-eclampsia in a low-middle income country where the incidence of pre-eclampsia
with organ complications is high. The study integrates different methods to investigate pre-eclampsia,
focusing on improved understanding of pathophysiology, prediction of organ complications, and
potentially future drug evaluation and discovery.
Description
CITATION: Bergman, L.; Bergman, K.; Langenegger, E.; Moodley, A.; Griffith-Richards, S.;Wikström, J.; Hall, D.; Joubert, L.; Herbst, P.; Schell, S.; et al. PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia. Cells
2021, 10, 959.
doi.10.3390/cells10040959
The original publication is available at: mdpi.com
The original publication is available at: mdpi.com
Keywords
Preeclampsia, Eclampsia, Perinatal death, Biobanks
Citation
Bergman, L.; Bergman, K.; Langenegger, E.; Moodley, A.; Griffith-Richards, S.;Wikström, J.; Hall, D.; Joubert, L.; Herbst, P.; Schell, S.; et al. PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia. Cells
2021, 10, 959.
doi.10.3390/cells10040959