Outcomes of assisted reproductive technologies in women 40 years and older at Tygerberg Hospital
Date
2021-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Stellenbosch : Stellenbosch University
Abstract
Objective: To evaluate the outcomes of ART in women age of 40 years and above
Design: Retrospective descriptive study
Setting: Tygerberg Academic Hospital, Reproductive Medicine Unit
Population: All women aged 40 years and above who had undergone ART
for infertility at the Tygerberg Reproductive Medicine Unit
Methods: Medical records of all patients who qualify to be included in the study were
reviewed and information regarding indications, treatment offered and outcomes were
retrieved and logged in proforma data spreadsheet.
Main outcome measures:
The primary outcome measures are the LBR, OPR & CPR.
Secondary outcome measures are number of oocytes retrieved, fertilization rates,
quality of embryos, cycle cancellation rates, miscarriage rates and complication rates
(multiple gestations or ovarian hyperstimulation rates [OHSS]).
Results: Ovulation induction was performed on 268 women (n=268) after excluding 2
women who had used oocyte donation. The biochemical pregnancy rate was 8,2% as 22
women had a positive βhCG test on day 10. Of these, 9 had a foetal heart rate on
ultrasound yielding a clinical pregnancy rate (CPR) of 3,3%. 3 pregnancies reached term
with 2 being documented as having given birth and 1 lost to follow up hence the live birth
rate was only 0,7% (2/268) per cycle and a miscarriage rate of 66,7%.
Conclusion: Reproductive outcomes in older women undergoing ART have a low
success rate as evidenced by the low live birth rate of 0,7% and miscarriage rate of 66%.
It is therefore essential that older women are thoroughly informed about expected
outcomes prior to them embarking on their ART journey
AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar
AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar
Description
Thesis (MMed)--Stellenbosch University, 2021.
Keywords
Assisted reproductive technologies, Reproductive techniques, Older Women -- Fertility