Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
BMC (part of Springer Nature)
Abstract
Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related
quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease
(ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana. This study sought
to assess QOL in patients with moderate to advanced CKD (not on dialysis) and establish its determinants.
Methods: We conducted a cross sectional observational study at the renal outpatient clinic at Komfo Anokye
Teaching Hospital (KATH). We collected demographic, clinical and laboratory data. A pretested self-administered
Research and Development corporation (RAND®) 36-Item Health Survey questionnaire was administered and QOL
scores in physical component summary (PCS) and mental component summary (MCS) were computed. Determinants of
QOL were established by simple and multiple linear regression. P value of < 0.05 was considered statistically significant.
Results: The study included 202 patients with CKD not on dialysis. There were 118(58.5%) males. Mean age was 46.7 ± 16.
2 years. The majority, 165(81.7%) of patients were on monthly salaries of less than GHS 500 (~USD 125). Chronic
glomerulonephritis was the most common cause of CKD in 118 (58.5%) patients followed by diabetes mellitus in 40
(19.8%) patients and hypertension in 19 (9.4%) patients. The median serum creatinine was 634.2 μmol/L (IQR 333–1248)
and the median eGFR was 7 ml/min/1.73m2 (IQR 3–16). The most common stage was CKD stage 5 accounting for 143
(71.1%), followed by CKD stage 4 with 45 (22.4%) of cases and 13 (6.5%) of CKD stage 3. The overall mean QOL score
was 40.3 ± 15.4. MCS score was significantly lower than PCS score (37.3 ± 10.8 versus 43.3 ± 21.6, P < 0.001). Multiple
linear regression showed that low monthly income (p = 0.002) and low haemoglobin levels (p = 0.003) were predictive
of overall mean QOL.
Conclusion: Patients with moderate to advanced CKD had low-income status, presented with advanced disease and
had poor QOL. Anaemia and low-income status were significantly associated with poor QOL.
Description
CITATION: Tannor, E. K., et al. 2019. Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study. BMC Nephrology, 20:122, doi:10.1186/s12882-019-1316-z.
The original publication is available at https://bmcnephrol.biomedcentral.com
The original publication is available at https://bmcnephrol.biomedcentral.com
Keywords
Chronic kidney disease, Quality of life, Kidney diseases -- Ghana
Citation
Tannor, E. K., et al. 2019. Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study. BMC Nephrology, 20:122, doi:10.1186/s12882-019-1316-z