Outbreak response intervention models of vaccine-preventable diseases in humans and foot-and- mouth disease in livestock : a protocol for a systematic review
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
BMJ Publishing Group
Abstract
Introduction Outbreaks of vaccine-preventable
diseases continue to threaten public health, despite
the proven effectiveness of vaccines. Interventions
such as vaccination, social distancing and palliative
care are usually implemented, either individually or in
combination, to control these outbreaks. Mathematical
models are often used to assess the impact of these
interventions and for supporting outbreak response
decision making. The objectives of this systematic
review, which covers all human vaccine-preventable
diseases, are to determine the relative impact of
vaccination compared with other outbreak interventions,
and to ascertain the temporal trends in the use of
modelling in outbreak response decision making. We will
also identify gaps and opportunities for future research
through a comparison with the foot-and-
mouth
disease
outbreak response modelling literature, which has good
examples of the use of modelling to inform outbreak
response intervention decision making.
Methods and analysis We searched on PubMed,
Scopus, Web of Science, Google Scholar and some
preprint servers from the start of indexing to 15 January
2020. Inclusion: modelling studies, published in English,
that use a mechanistic approach to evaluate the impact
of an outbreak intervention. Exclusion: reviews, and
studies that do not describe or use mechanistic models
or do not describe an outbreak. We will extract data from
the included studies such as their objectives, model
types and composition, and conclusions on the impact
of the intervention. We will ascertain the impact of
models on outbreak response decision making through
visualisation of time trends in the use of the models. We
will also present our results in narrative style.
Ethics and dissemination This systematic review will not
require any ethics approval since it only involves scientific
articles. The review will be disseminated in a peer-reviewed
journal and at various conferences fitting its scope
Description
CITATION: Azam, J. M., et al. 2020. Outbreak response intervention models of vaccine-preventable diseases in humans and foot-and- mouth disease in livestock : a protocol for a systematic review. BMJ Open, 10:e036172, doi:10.1136/bmjopen-2019-036172
The original publication is available at https://bmjopen.bmj.com/
Publication of this article was funded by the Stellenbosch University Open Access Fund
The original publication is available at https://bmjopen.bmj.com/
Publication of this article was funded by the Stellenbosch University Open Access Fund
Keywords
Vaccine-preventable diseases, Vaccines -- Effectiveness -- Mathematical models, Diseases -- Prevention -- Mathematical models, Foot-and-mouth disease -- Prevention -- Mathematical models
Citation
Azam, J. M., et al. 2020. Outbreak response intervention models of vaccine-preventable diseases in humans and foot-and- mouth disease in livestock : a protocol for a systematic review. BMJ Open, 10:e036172, doi:10.1136/
bmjopen-2019-036172