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High risk exposure to HIV among sexually active individuals who tested negative on rapid HIV Tests in the Tshwane District of South Africa - the importance of behavioural prevention measures

dc.contributor.authorMayaphi, Simnikiwe H.en_ZA
dc.contributor.authorMartin, Desmond J.en_ZA
dc.contributor.authorOlorunju, Steve A. S.en_ZA
dc.contributor.authorWilliams, Brian G.en_ZA
dc.contributor.authorQuinn, Thomas C.en_ZA
dc.contributor.authorStoltz, Anton C.en_ZA
dc.date.accessioned2019-10-07T13:48:06Z
dc.date.available2019-10-07T13:48:06Z
dc.date.issued2018-02-02
dc.identifier.citationMayaphi, S. H. et al. 2018. High risk exposure to HIV among sexually active individuals who tested negative on rapid HIV Tests in the Tshwane District of South Africa - the importance of behavioural prevention measures. PLoS ONE, 13(2):e0192357, doi:10.1371/journal.pone.0192357.
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0192357
dc.identifier.urihttp://hdl.handle.net/10019.1/106589
dc.descriptionCITATION: Mayaphi, S. H. et al. 2018. High risk exposure to HIV among sexually active individuals who tested negative on rapid HIV Tests in the Tshwane District of South Africa - the importance of behavioural prevention measures. PLoS ONE, 13(2):e0192357, doi:10.1371/journal.pone.0192357.
dc.descriptionThe original publication is available at https://journals.plos.org/plosone
dc.description.abstractObjective: To assess the prevalence of HIV risk behaviour among sexually active HIV sero-negative individuals in the Tshwane district of South Africa (SA). Methods: Demographic and HIV risk behaviour data were collected on a questionnaire from participants of a cross-sectional study that screened for early HIV infection using pooled nucleic acid amplification testing (NAAT). The study enrolled individuals who tested negative on rapid HIV tests performed at five HIV counseling and testing (HCT) clinics, which included four antenatal clinics and one general HCT clinic. Results: The study enrolled 9547 predominantly black participants (96.6%) with a median age of 27 years (interquartile range [IQR]: 23–31). There were 1661 non-pregnant and 7886 pregnant participants largely enrolled from the general and antenatal HCT clinics, respectively. NAAT detected HIV infection in 61 participants (0.6%; 95% confidence interval [CI]: 0.4–0.8) in the whole study. A high proportion of study participants, 62.8% and 63.0%, were unaware of their partner’s HIV status; and also had high prevalence, 88.5% and 99.5%, of recent unprotected sex in the general and pregnant population, respectively. Consistent use of condoms was associated with protection against HIV infection in the general population. Trends of higher odds for HIV infection were observed with most demographic and HIV risk factors at univariate analysis, however, multivariate analysis did not show statistical significance for almost all these factors. A significantly lower risk of HIV infection was observed in circumcised men (p <0.001). Conclusions: These data show that a large segment of sexually active people in the Tshwane district of SA have high risk exposure to HIV. The detection of newly diagnosed HIV infections in all study clinics reflects a wide distribution of individuals who are capable of sustaining HIV transmission in the setting where HIV risk behaviour is highly prevalent. A questionnaire that captures HIV risk behaviour would be useful during HIV counselling and testing to ensure that there is a systematic way of identifying HIV risk factors and that counselling is optimised for each individual. HIV risk behaviour surveillance could be used to inform relevant HIV prevention interventions that could be implemented at a community or population level.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192357
dc.format.extent14 pages
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.subjectHIV infections -- Risk factorsen_ZA
dc.subjectHIV Infections -- Preventionen_ZA
dc.subjectSexually transmitted diseases -- Preventionen_ZA
dc.subjectUnsafe sex -- South Africa -- Tshwaneen_ZA
dc.titleHigh risk exposure to HIV among sexually active individuals who tested negative on rapid HIV Tests in the Tshwane District of South Africa - the importance of behavioural prevention measuresen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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