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No evidence of HIV replication in children on antiretroviral therapy

dc.contributor.authorVan Zyl, Gert U.en_ZA
dc.contributor.authorKatusiime, Mary Graceen_ZA
dc.contributor.authorWiegand, Annen_ZA
dc.contributor.authorMcManus, William R.en_ZA
dc.contributor.authorBale, Michael J.en_ZA
dc.contributor.authorHalvas, Elias K.en_ZA
dc.contributor.authorLuke, Brianen_ZA
dc.contributor.authorBoltz, Valerie F.en_ZA
dc.contributor.authorSpindler, Jonathanen_ZA
dc.contributor.authorLaughton, Barbaraen_ZA
dc.contributor.authorEngelbrecht, Susanen_ZA
dc.contributor.authorCoffin, John M.en_ZA
dc.contributor.authorCotton, Mark F.en_ZA
dc.contributor.authorShao, Weien_ZA
dc.contributor.authorMellors, John W.en_ZA
dc.contributor.authorKearney, Mary F.en_ZA
dc.date.accessioned2018-10-18T14:04:36Z
dc.date.available2018-10-18T14:04:36Z
dc.date.issued2017-04
dc.identifier.citationVan Zyl, G. U., et al. 2017. No evidence of HIV replication in children on antiretroviral therapy. Journal of Clinical Investigation, 127(10):3827-3834, doi:10.1172/JCI94582
dc.identifier.issn1558-8238 (online)
dc.identifier.issn0021-9738 (print)
dc.identifier.otherdoi:10.1172/JCI94582
dc.identifier.urihttp://hdl.handle.net/10019.1/104569
dc.descriptionCITATION: Van Zyl, G. U., et al. 2017. No evidence of HIV replication in children on antiretroviral therapy. Journal of Clinical Investigation, 127(10):3827-3834, doi:10.1172/JCI94582.
dc.descriptionThe original publication is available at https://www.jci.org
dc.description.abstractENGLISH ABSTRACT: It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the lymph nodes, a high priority should be placed on improving ART regimes to target these sites. To investigate the question of ongoing viral replication on current ART regimens, we analyzed HIV populations in longitudinal samples from 10 HIV-1–infected children who initiated ART when viral diversity was low. Eight children started ART at less than ten months of age and showed suppression of plasma viremia for seven to nine years. Two children had uncontrolled viremia for fifteen and thirty months, respectively, before viremia suppression, and served as positive controls for HIV replication and evolution. These latter 2 children showed clear evidence of virus evolution, whereas multiple methods of analysis bore no evidence of virus evolution in any of the 8 children with viremia suppression on ART. Phylogenetic trees simulated with the recently reported evolutionary rate of HIV-1 on ART of 6 × 10⁻⁴ substitutions/site/month bore no resemblance to the observed data. Taken together, these data refute the concept that ongoing HIV replication is common with ART and is the major barrier to curing HIV-1 infection.en_ZA
dc.description.urihttps://www.jci.org/articles/view/94582
dc.format.extent9 pages : illustrationsen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society for Clinical Investigationen_ZA
dc.subjectReplication of virusesen_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectHIV (Viruses) -- Children -- Treatmenten_ZA
dc.titleNo evidence of HIV replication in children on antiretroviral therapyen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAmerican Society for Clinical Investigationen_ZA


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