Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas

Ochodo, Eleanor Atieno ; Gopalakrishna, Gowri ; Spek, Bea ; Reitsma, Johannes B. ; Van Lieshout, Lisette ; Polman, Katja ; Lamberton, Poppy ; Bossuyt, Patrick M. M. ; Leeflang, Mariska M. G. (2015-03-11)

CITATION: Ochodo, E. A. et al. 2015. Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas. Cochrane Database of Systematic Reviews, 3: Art. No.: CD009579, doi:10.1002/14651858.CD009579.pub2.

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Article

Background : Point-of-care (POC) tests for diagnosing schistosomiasis include tests based on circulating antigen detection and urine reagent strip tests. If they had sufficient diagnostic accuracy they could replace conventional microscopy as they provide a quicker answer and are easier to use. Objectives : To summarise the diagnostic accuracy of: a) urine reagent strip tests in detecting active Schistosoma haematobium infection, with microscopy as the reference standard; and b) circulating antigen tests for detecting active Schistosoma infection in geographical regions endemic for Schistosoma mansoni or S. haematobium or both, with microscopy as the reference standard. Search methods : We searched the electronic databases MEDLINE, EMBASE, BIOSIS,MEDION, and Health Technology Assessment (HTA) without language restriction up to 30 June 2014. Selection criteria : We included studies that used microscopy as the reference standard: for S. haematobium, microscopy of urine prepared by filtration, centrifugation, or sedimentation methods; and for S. mansoni, microscopy of stool by Kato-Katz thick smear. We included studies on participants residing in endemic areas only.

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