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Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes : a randomised controlled trial

dc.contributor.authorChingono, R.en_ZA
dc.contributor.authorMebrahtu, H.en_ZA
dc.contributor.authorMupambireyi, Z.en_ZA
dc.contributor.authorSimms, V.en_ZA
dc.contributor.authorWeiss, H. A.en_ZA
dc.contributor.authorNdlovu, P.en_ZA
dc.contributor.authorCharasika, F.en_ZA
dc.contributor.authorTomlinson, M.en_ZA
dc.contributor.authorCluver, L. D.en_ZA
dc.contributor.authorCowan, F. M.en_ZA
dc.contributor.authorSherr, L.en_ZA
dc.date.accessioned2018-07-16T05:49:40Z
dc.date.available2018-07-16T05:49:40Z
dc.date.issued2018-07-09
dc.identifier.citationChingono, R. et al. 2018. Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes : a randomised controlled trial. BMC Pediatrics, 18:222, doi:10.1186/s12887-018-1201-0.
dc.identifier.issn1471-2431 (online)
dc.identifier.otherdoi:10.1186/s12887-018-1201-0
dc.identifier.urihttp://hdl.handle.net/10019.1/104140
dc.descriptionCITATION: Chingono, R. et al. 2018. Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes : a randomised controlled trial. BMC Pediatrics, 18:222, doi:10.1186/s12887-018-1201-0.
dc.descriptionThe original publication is available at https://bmcpediatr.biomedcentral.com
dc.description.abstractBackground: HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents. Methods: The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0–24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted. Discussion: The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments. Trial registration: This trial is registered with the Pan African Clinical Trials Registry ( www.pactr.org), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered).
dc.description.sponsorshipUSAID-PEPFAR
dc.description.urihttps://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-018-1201-0
dc.format.extent10 pages
dc.language.isoen
dc.publisherBioMed Central
dc.subjectChild developmenten_ZA
dc.subjectInfants -- Developmenten_ZA
dc.subjectAIDS (Disease) in childrenen_ZA
dc.subjectHIV infections -- Treatmenten_ZA
dc.subjectHIV infections -- Zimbabween_ZA
dc.titleEvaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes : a randomised controlled trialen_ZA
dc.typeArticle
dc.date.updated2018-07-15T03:28:29Z
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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