Masters Degrees (Obstetrics and Gynaecology)

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Browsing Masters Degrees (Obstetrics and Gynaecology) by Subject "Assisted reproductive technologies"

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    Outcomes of assisted reproductive technologies in women 40 years and older at Tygerberg Hospital
    (Stellenbosch : Stellenbosch University, 2021-12) Nkangana, Nontando; Matsaseng, Thabo; Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Obstetrics and Gynaecology.
    Objective: To evaluate the outcomes of ART in women age of 40 years and above Design: Retrospective descriptive study Setting: Tygerberg Academic Hospital, Reproductive Medicine Unit Population: All women aged 40 years and above who had undergone ART for infertility at the Tygerberg Reproductive Medicine Unit Methods: Medical records of all patients who qualify to be included in the study were reviewed and information regarding indications, treatment offered and outcomes were retrieved and logged in proforma data spreadsheet. Main outcome measures: The primary outcome measures are the LBR, OPR & CPR. Secondary outcome measures are number of oocytes retrieved, fertilization rates, quality of embryos, cycle cancellation rates, miscarriage rates and complication rates (multiple gestations or ovarian hyperstimulation rates [OHSS]). Results: Ovulation induction was performed on 268 women (n=268) after excluding 2 women who had used oocyte donation. The biochemical pregnancy rate was 8,2% as 22 women had a positive βhCG test on day 10. Of these, 9 had a foetal heart rate on ultrasound yielding a clinical pregnancy rate (CPR) of 3,3%. 3 pregnancies reached term with 2 being documented as having given birth and 1 lost to follow up hence the live birth rate was only 0,7% (2/268) per cycle and a miscarriage rate of 66,7%. Conclusion: Reproductive outcomes in older women undergoing ART have a low success rate as evidenced by the low live birth rate of 0,7% and miscarriage rate of 66%. It is therefore essential that older women are thoroughly informed about expected outcomes prior to them embarking on their ART journey