Department of Biomedical Sciences
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Browsing Department of Biomedical Sciences by Subject "6-Hydroxytetrahydroisoquinolines"
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- ItemSynthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation(ARKAT USA, 2019) Mabank, Tanya; Alexandre, Kabamba B.; Pelly, Stephen C.; Green, Ivan R.; Van Otterlo, Willem A. L.ENGLISH ABSTRACT: 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.