Browsing by Author "Rosenstrauch, W. J. C. J."

Now showing 1 - 4 of 4
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    Hodgkin's disease and acute promyelocytic leukaemia : a case report
    (Health & Medical Publishing Group, 1980) Rosenstrauch, W. J. C. J.; Van der Merwe, A. M.; King, J. B.
    A case of Hodgkin's disease is reported in which acute promyelocytic leukaemia developed within 5 months of initiation of chemotherapy. Only 3 other cases, possibly of a similar nature, were found in the literature; these had occurred 15, 77, and 226 months respectively after the initial diagnosis of Hodgkin's disease.
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    Lipoid proteinosis : a case report
    (Health & Medical Publishing Group, 1984) Hardcastle, S. W.; Rosenstrauch, W. J. C. J.
    A 31-year-old Coloured man was admitted to Tygerberg Hospital in 1981 with hoarseness, hyperkeratotic skin lesions and nodules on the eyelids. There was a history of an episode of loss of consciousness. Skull radiographs demonstrated bilateral symmetrical calcifications in the temporal region. Skin biopsy was consistent with a diagnosis of lipoid proteinosis.
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    Mielomatose in Suid-Afrika : neem die insidensie toe?
    (Health & Medical Publishing Group, 1984) Brink, S.; Rosenstrauch, W. J. C. J.; Van der Merwe, A. M.
    Multiple myeloma was once thought to be extremely rare, with an estimated frequency of less than 0.1% of all malignant tumours. In 1964 Oettle reported that available mortality statistics showed 171 deaths in the 10-year period 1949-1958 in the RSA for Whites, Coloureds and Asiatics aged 20 years and older. During the 5-year period 1968-1972 however, 222 cases of multiple myeloma appeared in the mortality records of the Central Statistical Service. Since 1964 150 new cases have been diagnosed at Karl Bremer Hospital and later at Tygerberg Hospital, with an average of 15 new cases per year from 1978 to 1982. Four examples of familial myelomatosis and one of familial macroglobulinaemia were found at these two hospitals. On 1 January 1983, 48 patients were on record who had attended the Tygerberg Hospital Haematology Clinic and 78 who had attended Groote Schuur Hospital, giving a total of 126 patients under treatment in the Western Cape during 1982. In addition, for the 6-year period from January 1971 to December 1976, 162 patients were reported from the haematology clinics at the Johannesburg General Hospital and Baragwanath Hospital. The true incidence of multiple myeloma in the RSA is problematical because there is no National Cancer Register; establishment of such a register would need the co-operation of all doctors in the country.
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    Prognostic factors in multiple myeloma
    (Health and Medical Publishing Group (HMPG), 1986-01) Brink, Stefanie; Bradshaw, D.; Rosenstrauch, W. J. C. J.; Van der Merwe, Aletta M.
    All patients with multiple myeloma seen over a 9-year period at Tygerberg Hospital were studied retrospectively. Presentation data of 144 patients, as well as individual laboratory results were included in the survival analysis. Cox's proportional hazard model (a non-parametric multivariate regression method) was used to predict survival and divide patients into prognostic groups. The relationship between pairs of variables at the time of diagnosis was investigated. The survival of groups of patients was compared using the generalized Wilcoxon and Savage tests. The association of the following factors with prognosis were again substantiated: haemoglobin; serum creatinine, urea and albumin; percentage of plasma cells in the bone marrow aspirate and trephine biopsy specimen; and the number of lytic lesions on skeletal radiography. The following factors were not substantiated: serum uric acid, light-chain proteinuria, age at presentation of the disease and IgG rather than the IgA class. In addition, a higher serum monoclonal peak size at presentation of the disease, and a more rapid fall in the abnormal serum monoclonal peak within the first 40 days after commencing treatment were associated with a significantly longer survival.