Browsing by Author "Opie, Lionel H."

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    Beta-blockers and the treatment of hypertension : it is time to move on
    (Clinics Cardiv Publishing, 2007-12) Wiysonge, Charles Shey; Volmink, Jimmy; Opie, Lionel H.
    Existing solid scientific evidence with hard outcome data should be the basis for treatment guidelines, and where such evidence is lacking, we must invest in research. A case in point is the initiation of antihypertensive treatment with a beta-blocker. Beta-blockers are pharmacological agents that block the action of endogenous catecholamines on beta-adrenergic receptors, part of the sympathetic nervous system which mediates the ‘fight or flight’ response.
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    Influence of tumour necrosis factor alpha on the outcome of ischaemic postconditioning in the presence of obesity and diabetes
    (Hindawi, 2012) Lacerda, Lydia; Opie, Lionel H.; Lecour, Sandrine
    Obesity and diabetes contribute to cardiovascular disease and alter cytokine profile. The cytokine, tumour necrosis factor alpha (TNFα), activates a protective signalling cascade during ischaemic postconditioning (IPostC). However, most successful clinical studies with IPostC have not included obese and/or diabetic patients. We aimed to investigate the influence of TNFα on the outcome of IPostC in obese or diabetic mice. TNF knockout or wildtype mice were fed for 11 weeks with a high carbohydrate diet (HCD) to induce modest obesity. Diabetes was induced in a separate group by administration of a single intraperitoneal injection of streptozotocin. Hearts were then isolated and subjected to ischaemia (35 min of global ischaemia) followed by 45 min of reperfusion. HCD increased body weight, plasma insulin and leptin levels while the glucose level was unchanged. In streptozotocintreated mice, blood glucose, plasma leptin and insulin were altered. Control, obese or diabetic mice were protected with IPostC in wiltype animals. In TNF knockout mice, IPostC failed to protect control and diabetic hearts while a slight protection was observed in obese hearts. Our data confirm a bidirectional role for TNFα associated with the severity of concomitant comorbidities and suggest that diabetic and/or modestly obese patients may still benefit from IPostC.