Browsing by Author "Mansvelt, E. P. G."
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- ItemDie rol van matige wynverbruik tydens maaltye in die voorkoming van hartsiektes(Medpharm Publications, 2000) Van Velden, D. P.; Mansvelt, E. P. G.pidemiological evidence consistently link moderate red wine consumption with reduced incidence of cardiovascular disease. lt has been found that there is a much lower mortality from cardiovascular disease, mainly coronary artery disease (CAD),in the countries borderingthe Mediterranean compared with that in Northern Europe. This was coined "The French Paradox", describing the phenomenon that the French have a low incidence of CAD despite the hct that they follow a diet rich in saturated fat. lt is well known that the French regularly consume red wine with their meals. Platelet aggregability plays an important role in the pathogenesis of CAD.Various phytochemicals in red wine may reduce platelet rggregation, serum lipid peroxidation and hence thrombosis. We investigated the effects of regular moderate red wine consumption on platelet aggregability ex vivo and on the serum lipid profile and antioxidant status.We conclude
- ItemThe effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron-deficiency(1994) Smuts, C. M.; Tichelaar, H. Y.; Van Jaarsveld, P. J.; Badenhorst, C. J.; Kruger, M.; Laubscher, R.; Mansvelt, E. P. G.; Benade, A. J. S.An intervention study was designed to evaluate the fatty acid (FA) status of children aged 6-11 years before and after iron fortification. Iron deficient (ID) and matched controls without ID (n = 30) were selected. All children received soup (160 mL) fortified with 20 mg iron and 100 mg vitamin C for 15 weeks on school days. Measurements before and after intervention included dietary intake, haematological and iron status and FA composition of plasma and erythrocyte membranes (EMBs). The prevalence of low plasma ferritin concentration and transferrin saturation decreased in the ID children by 40% and 56%, respectively, with intervention. Plasma FAs reflected dietary FA intake. In comparison with controls, the ID group presented with increased percentage total saturated FAs (SFAs; p = 0.0002) in their EMB phosphatidylcholine (PC) and reduced percentage total polyunsaturated FAs (PUFAs; p = 0.0037) before intervention. Lower total n-3 FAs (p = 0.0070) including eicosapentaenoic acid (EPA; p = 0.0034), docosapentaenoic acid (DPA; p = 0.0048) and docosahexaenoic acid (DHA; p = 0.0058) were observed in the ID group. The EMB phosphatidylethanolamine (PEA) of the ID children presented with lower percentages of α-linolenic acid (ALA; p = 0.0001), EPA (p = 0.0051) and DHA (p = 0.0084) compared to controls before intervention. Iron intervention was associated with an increase (p < 0.05) in the percentage of n-3 FAs in the EMB-PC and -PEA of the ID group to percentages comparable to that in the control group. It appears that iron status can influence FA metabolism of specific n-3 FAs in the EMBs of young children.
- ItemWine and health : research in action(Academy of Science of South Africa, 2001) Armstrong, G. O.; Lambrechts, M. G.; Mansvelt, E. P. G.; Van Velden, D. P.; Pretorius, I. S.Is it possible that wine may indeed be the world's oldest medicine? Until the 18th century, wine played an integral role in medical practice. Not only was it safer to drink than most available water but its alcohol, antioxidant and acid content inhibited the growth of many spoilage and pathogenic organisms. The paradigm shifted in the second half of the 20th century, when alcohol consumption, including wine drinking, had become the target of health campaigners who, with some success, demanded warning labels on wine bottles. Substantial medical evidence, summarized in this article, was accumulated during the 1990s and indicated that the moderate consumption of especially red wine can reduce the incidence of coronary heart disease. Today it is perceived, and generally accepted, that moderate wine drinking can be socially beneficial, and can also be effective in the management of stress and reducing coronary heart disease. The prudent wine drinkers, however, continue to monitor their drinking habits so as to ensure that the benefits exceed the risks.