Browsing by Author "Malan, C."

Now showing 1 - 7 of 7
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    Adenosine deaminase estimations in the differentiation of pleural effusions
    (Health & Medical Publishing Group, 1982-10) Maritz, F. J.; Malan, C.; Le Roux, I.
    Adenosine deaminase (ADA) estimations were performed on the pleural fluid from 368 effusions. The mean (±SD) ADA concentration in tuberculous effusions was 92.11 ± 37.05 U/l, and these values were found to be highly statistically different from the 23.3 ± 13.15 U/l in secondary malignant tumours of the pleura, the 34.86 ± 14.2 U/l in mesotheliomas, and the 23.81 ± 15.07 U/l in pulmonary embolism. The ADA values of 64.3 ± 44.95 UlI in lymphoproliferative disorders were less significantly different. No statistical difference could be found between values in the tuberculous group and the ADA levels of 97.57 ± 82 U/l found in para-infective effusions, but these could be distinguished from each other by microscopic examination of the pleural fluid. The importance of ADA estimations in the diagnosis and differentiation of tuberculous effusions is discussed and the role of microscopy is emphasized.
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    Ascaris lumbricoides and allergic asthma. A new perspective
    (Health & Medical Publishing Group, 1979-10) Joubert, J. R.; De Klerk, H. C.; Malan, C.
    ENGLISH ABSTRACT: Infestation of humans with the parasite Ascaris lumbricoides may induce high total serium IgE levels, but the influence of this immunogenic respone on allergic asthma has not been defined. In this study, the specific antiparasitic IgE-mediated response as determined by skin-prick testing was related to the incidence of allergic asthma in Ascaris-infested patients. A limited number - 17% of the non-allergic controls and 51% of the allergic asthmatics - had a clinically detectable immunogenic response to the parasite. The predicted incidence of asthma was significantly higher than the observed incidence in the subjects in whom the Ascaris skin test was positive. This was not found in subjects in whom the Ascaris skin test was negative. Inhalation of Ascaris antigen induced asthmatic reactions in 7 of 8 patients who were Ascaris-positive on skin testing, but not in the negative controls. The groups of patients who repond immunogenically to parasite infestation need to be defined, as they may be predisposed to allergic diseases such as asthma.
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    Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis
    (Health & Medical Publishing Group, 1986) Donald, P. R.; Malan, C.
    The value of cerebrospinal fluid (CSF) lactate and lactate dehydrogenase (LD) activity in the rapid diagnosis of meningitis was investigated in three groups of patients - a 'no meningitis', an aseptic meningitis and a bacterial meningitis group. The sensitivity achieved in the detection of bacterial meningitis by CSF lactate values of 2,85 mmol/l (93,8%) and 3,9 mmol/l (89,6%) was greater than that reached by conventional chemical investigations using a CSF protein value of 1 g/l (81,5%) or a CSF glucose value of 2,2 mmol/l (68,8%) as the indicator. The sensitivity of an absolute CSF LD value of 40 U/l (86,3%) in the detection of bacterial meningitis was slightly lower than that of a CSF protein value of 1 g/l (87%) and better than the sensitivity of either a CSF/serum LD ratio of 0,1:1,0 (83,9%) or a CSF glucose level of 2,2 mmol/l (76,3%). As with conventional CSF chemistry, both investigations may give normal values in the presence of bacterial meningitis.
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    Hormonal placental functions and intrauterine growth retardation in patients with positive contraction stress tests
    (Health & Medical Publishing Group, 1981) Odendaal, H. J.; Malan, C.; Oosthuizen, J.
    Human placental lactogen (HPL) and urinary and serum oestriol levels were studied in patients in whom the contraction stress test was positive. After birth the infants were assessed for growth retardation. Low PHL, serum oestriol and urinary oestrogen levels were found in 66%, 30% and 15% of patients respectively. Gestational ages were known in 148 patients, of whom 72 (49%) had infants whose weights were below the 10th percentile for gestational age. HPL values were low in 81% of mothers who gave birth to growth-retarded infants, but serum and urinary oestriol levels were low in only 43% and 21% respectively. When both a positive stress test and a low HPL value were present 69% of infants were growth retarded. The incidence of growth retardation rose to 85% when both HPL and serum oestriol levels were abnormal in patients with positive contraction stress tests. In this study estimation of HPL levels was found to be superior to that of oestrogen levels in detecting growth-retarded infants.
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    Isovaleric acidaemia in two South African children
    (Health & Medical Publishing Group, 1977) Malan, C.; Neethling, A. C.; Shanley, B. C.
    Two siblings who were repeatedly admitted to hospital with acute episodes of vomiting, dehydration and coma were found to be suffering from isovaleric acidaemia. This condition is a rare inherited abnormality of leucine metabolism, which is frequently fatal in the early weeks of life and leads to mental retardation in a high proportion of those who survive early attacks. However, both out patients were of normal intelligence. The clinical presentation, biochemical defect, diagnosis and suggested therapies are reviewed.
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    Management development of junior officers in the SA Army
    (Stellenbosch : Stellenbosch University, 1999-12) Malan, C.; Schwella, E.; Stellenbosch University. Faculty of Economic and Management Sciences. Dept. of School of Public Leadership.
    ENGLISH SUMMARY: Guided by the transformation process of the Public Service, the SA National Defence Force (SANDF) transformation process, based on the Leadership, Command, and Management Philosophy (LCAMPS-model), was launched on 27 April 1994. The SA Army as component of the SANDF, requires skilled commanders and leaders to manage in the future. A lack of management content was observed in the development training of junior officers in the SA Army. This study is aimed at investigating the alleged insufficient management development of junior officers during their training in the SA Army. A study of the theory of management and the development thereof is undertaken. This is supplemented by a quantitative analysis of the actual job descriptions, performance evaluation and development training of junior officers in the SA Army. After comparing the theory with practice, it was found that current development training of junior officers does not sufficiently include management functions and skills. The present training must be changed to include management development, for Junior officers to act as future managers.
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    Urinary porphyrins and porphyrin precursors in normal pregnancy. Relationship to urinary total oestrogen excretion
    (Health and Medical Publishing Group (HMPG), 1975) De Klerk, M.; Weideman, A.; Malan, C.; Shanley, B. C.
    The relationship between urinary excretion of porphyrins, porphyrin precursors and total oestrogens in normal pregnancy was investigated. Significant increases in total oestrogen, delta aminolaevulinic acid (ALA) and coproporphyrin (COPRO) excretion were noted. However, no close correlation was found between total oestrogen excretion and urinary output of ALA and COPRO. The results suggest that the observed increases in ALA and COPRO excretion during pregnancy may not simply be the result of steroid mediated induction of hepatic haem biosynthesis, as has been proposed.