Browsing by Author "Kelbe, Lisa Suzanne"

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    The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines
    (Stellenbosch : Stellenbosch University, 2017-12) Kelbe, Lisa Suzanne; Swart, P.; Swart, Amanda C.; Stellenbosch University. Faculty of Science. Dept. of Biochemistry.
    ENGLISH ABSTRACT: This study describes: 1. The preparation of a biologically active methanol extract from S.tuberculatiformis. 2. The demonstration of biological activity for both the crude S.tuberculatiformis extract and Compound A. 3. The effects of the crude S.tuberculatiformis extract and Compound A on nuclear translocation of the androgen and estrogens receptors in three different prostate cancer cell-lines. 4. Cell viability assays demonstrating the potency (IC50) for Compound A and the crude S.tuberculatiformis extract between the three prostate cancer cell-lines. 5. Caspase assays to demonstrate apoptosis for the crude S.tuberculatiformis extract and Compound A in prostate cancer celllines.