Browsing by Author "Joubert, J. J."

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    Blood oxygen saturation levels during conscious sedation with midazolam. A report of 16 cases
    (Health & Medical Publishing Group, 1986) Roelofse, J. A.; Van der Bijl, P.; Joubert, J. J.; Breytenbach, H. S.
    In a double-blind randomized study on 16 healthy individuals, two groups of subjects (8 in each group) received either midazolam (Dormicum; Roche) 0,1 mg/kg or placebo intravenously for conscious sedation during oral surgical procedures. Oxygen saturation of the blood was measured at different stages. Ten minutes after administration of the drug, the percentage oxygen saturation was significantly lower (P<0.05) in the midazolam group than in the placebo group.
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    Genital tuberculosis at Tygerberg Hospital : prevalence, clinical presentation and diagnosis
    (Health & Medical Publishing Group, 1992) Margolis, K.; Wranz, P. A. B.; Kruger, T. F.; Joubert, J. J.; Odendaal, H. J.
    Over a period of 30 months (1 July 1986-31 December 1988) 57 cases of genital tuberculosis were diagnosed at Tygerberg Hospital. Forty of these cases were diagnosed as a result of routine screening in 650 patients who presented with infertility and the other 17 were diagnosed in patients admitted to the gynaecological wards. The prevalence in patients presenting with infertility was 6,15%. The commonest gynaecological presenting symptom was infertility (73,7%). Dysmenorrhoea in 29,8% and deep dyspareunia in 12,3% were the only other frequently occurring gynaecological symptoms. Menstruation was normal in 50 patients (87,7%). Seven per cent of patients were postmenopausal. Abdominal symptoms were only present in 15,8%. These findings re-emphasise that genital tuberculosis is often a disease absent of or with few symptoms. General, abdominal and pelvic examinations were normal in 56,1% of patients and even when clinical signs were present they were nonspecific. Menstrual fluid collection and culture proved to be the most reliable diagnostic procedure, since it was positive in 11 patients in whom premenstrual endometrial sample cultures were negative and also in 17 patients in whom histological examination of premenstrual endometrial samples for tuberculosis were negative. The possible reasons for this and its clinical importance are discussed. Other than histological examination of operation and/or biopsy specimens, special investigations proved to be of little help in the diagnosis of genital tuberculosis.
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    The usefulness of cerebrospinal fluid tests for neurosyphilis
    (Health & Medical Publishing Group, 1994) Russouw, H. G.; Roberts, M. C.; Emsley, R. A.; Joubert, J. J.
    To determine the usefulness of cerebrospinal fluid (CSF) tests for syphilis at a large academic hospital, clinical and laboratory data on 644 patients in whom such testing was requested over a 12-month period were analysed. In 198 cases (31%) the Treponema pallidum haemagglutination (TPHA) screening test could not be performed because of insufficient fluid. Thirty-eight of the remaining patients were diagnosed as having active neurosyphilis. Examination of 22 files of patients who had a positive TPHA and fluorescent treponemal antibody absorption (FTA-Abs) test together with a negative CSF Venereal Disease Research Laboratory (VDRL) test revealed that other CSF measures indicating disease activity (CSF protein, cells or IgG index) were not utilised optimally. In 10 (45%) of these patients neurosyphilis was not diagnosed despite either abnormal or incomplete CSF biochemical analysis, indicating that if the CSF VDRL is used as the sole marker for disease activity, some cases of neurosyphilis are likely to be missed.