Browsing by Author "Hoving, J. Claire"

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    Emergomyces : the global rise of new dimorphic fungal pathogens
    (Public Library of Science, 2019) Schwartz, Ilan S.; Govender, Nelesh P.; Sigler, Lynne; Jiang, Yanping; Maphang, Tsidiso G.; Toplis, Barbra; Botha, Alfred; Dukik, Karolina; Hoving, J. Claire; Munoz, Jose F.; De Hoog, Sybren; Cuomo, Christina A.; Colebunders, Robert; Kenyon, Chris
    Unknown until recently, the genus Emergomyces is composed of dimorphic fungi with human pathogenic potential. Five described species have been implicated as causes of disease in immunocompromised persons on at least 4 continents. In some regions, such as southern Africa, this disease, emergomycosis, is now the most commonly diagnosed dimorphic fungal infection. Herein, we review the history of these fungi, clinical features and pathogenesis of disease, what is known of their biology, and future research directions.
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    Emergomyces africanus in soil, South Africa
    (Centers for Disease Control and Prevention, 2018-02) Schwartz, Ilan S.; Lerm, Barbra; Hoving, J. Claire; Kenyon, Chris; Horsnell, William G.; Basson, W. Joan; Otieno-Odhiambo, Patricia; Govender, Nelesh P.; Colebunders, Robert; Botha, Alfred
    We detected Emergomyces africanus, a thermally dimorphic fungus that causes an HIV-associated systemic mycosis, by PCR in 18 (30%) of 60 soil samples from a wide range of habitats in South Africa. Direct and indirect culture techniques were unsuccessful. Experimental intraperitoneal inoculation of conidia induced murine disease.