Browsing by Author "Ferreira, Maria Magdalena"

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    A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa
    (Stellenbosch : Stellenbosch University, 2014-03) Ferreira, Maria Magdalena; Rosenkranz, B.; Stellenbosch University. Facutly of Medicine and Health Sciences. Department of Medicine. Division of Clinical Pharmacology.
    ENGLISH SUMMARY : Thiopurine medications e.g. Azathioprine and 6-Mercaptopurine are metabolized by the thiopurine methyltransferase (TPMT) enzyme. This enzyme activity is highly variable due to polymorphism of the TPMT gene. TPMT genotyping can be performed to tailor the treatment with thiopurine medications specifically to the patient's TPMT activity.