Browsing by Author "Fernandes, Manuel A."
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- ItemCyclization of enaminones derived from N-phenacylpyrrolidin-2-ones to pyrrolizines under acidic conditions(ARKAT USA, 2020) Morgans, Garreth L.; Fernandes, Manuel A.; Van Otterlo, Willem A. L.; Michael, Joseph P.ENGLISH ABSTRACT: Several N-phenacyl enaminones, prepared by Eschenmoser sulfide contraction between Nphenacylpyrrolidine-2-thiones and a range of substituted phenacyl halides, were transformed into 2,3- dihydro-1H-pyrrolizines when treated with acetic acid or silica gel. Yields of the bicyclic products were in the range 57–100% depending on the route followed. Some further reactions of the newly formed pyrrole rings are also reported.