Browsing by Author "Chiliza, B."

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    Factors moderating the relationship between childhood trauma and premorbid adjustment in first-episode schizophrenia
    (Public Library of Science, 2017-01-20) Kilian, Sanja; Burns, J. K.; Seedat, S.; Asmal, L.; Chiliza, B.; Du Plessis, S.; Du Plessis, M. R.; Kidd, Michael; Emsley, Robin A.
    Childhood trauma is a recognised risk factor for schizophrenia. It has been proposed that childhood trauma interferes with normal neurodevelopment, thereby establishing a biological vulnerability to schizophrenia. Poor premorbid adjustment is frequently a precursor to schizophrenia, and may be a manifestation of neurodevelopmental compromise. We investigated the relationship between childhood trauma and premorbid adjustment in 77 patients with first-episode schizophrenia spectrum disorders. We also investigated possible mediating roles for other selected risk factors in the relationship. We found several significant correlations between different trauma types and both social and academic premorbid adjustment from childhood to late adolescence. There were no significant moderating effects for family history of schizophrenia or family history of psychiatric disorder. History of obstetric complications, substance abuse and poor motor coordination weakened some of the associations between childhood trauma and premorbid adjustment, while poor sequencing of motor acts strengthened the association. Our results confirm previous studies indicating an association between childhood trauma and premorbid adjustment. Results indicate a general rather than specific association, apparent with different types of trauma, and affecting both social and academic components of premorbid adjustment across childhood, early and late adolescence. Further, our results suggest a complex interplay of various risk factors, supporting the notion of different pathways to psychosis.
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    The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: Summaries of oral sessions
    (2010) Baharnoori, M.; Bartholomeusz, C.; Boucher, A. A.; Buchy, L.; Chaddock, C.; Chiliza, B.; Focking, M.; Fornito, A.; Gallego, J. A.; Hori, H.; Huf, G.; Jabbar, G. A.; Kang, S. H.; El-Kissi, Y.; Merchan-Naranjo, J.; Modinos, G.; Abdel-Fadeel, N. A. M.; Neubeck, A. K.; Ng, H. P.; Novak, G.; Owolabi, O. O.; Prata, D. P.; Rao, N. P.; Riecansky, I.; Smith, D. C.; Souza, R. P.; Thienel, R.; Trotman, H. D.; Uchida, H.; Woodberry, K. A.; O'Shea, A.; DeLisi, L. E.
    The 2nd Schizophrenia International Research Society Conference, was held in Florence, Italy, April 10-15, 2010. Student travel awardees served as rapporteurs of each oral session and focused their summaries on the most significant findings that emerged from each session and the discussions that followed. The following report is a composite of these reviews. It is hoped that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. © 2010 Elsevier B.V.