Neurology

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Browsing Neurology by Author "De Graaf, A. S."

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    Diagnostic problems of leptomeningeal lymphoma : a report of 3 cases
    (Health & Medical Publishing Group, 1987) Gardiner, J.; De Graaf, A. S.; Hewlett, R. H.
    Three cases are presented in which occult lymphoreticular malignant tumour spread to the spinal and cranial subarachnoid spaces inducing a problematic neurological illness characterised by poorly localised neuralgic pain, slowly progressive paresis and, in 2 patients, papilloedema with computed tomographic evidence of ventricular dilatation. Despite intensive investigations, diagnosis was only achieved at autopsy. A progressive disturbance of spinal and cranial nerve function should direct the attention of the clinician to the possibility of diffuse meningeal involvement by a malignant or inflammatory process.
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    The spectrum of disease in weakness and wasting of the quadriceps muscles : case reports
    (Health and Medical Publishing Group -- HMPG, 1982-01) De Graaf, A. S.; Hewlett, R. H.
    Three patients who presented with weakness and wasting of the quadriceps muscles ('quadriceps myopathy'), are reported. In each, electrophysiological and biopsy studies revealed completely different pathological processes, including motor unit disease, polymyositis and muscular dystrophy. Double biopsies performed in 2 of the patients showed the disease process to involve upper as well as lower limbs. The diffuse and heterogeneous nature of this form of neuromuscular disease is confirmed.
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    Standards for the assessment of visual evoked potentials in an ethnically heterogeneous adult population
    (Health and Medical Publishing Group -- HMPG, 1985-02) De Graaf, A. S.; Lombard, C. J.; Hart, G. L.
    Visual evoked potentials (VEPs) were recorded by chequerboard pattern-reversal stimulation in 276 normal adult subjects aged 15-73 years. The sample comprised comparable white, coloured and black groups of both sexes. Significantly shorter latencies of the major positive component were found in both male and female black subjects compared with those in whites. No significant differences were found between the amplitudes in the different population groups, but females in each population group showed significantly higher amplitudes of the major positive component than males. There was a close relationship between latency and amplitude for both right and left eyes. Except in coloured females, a nonlinear relationship of the major positive component with age was demonstrated, the shortest latency being at about 35 years of age. It is suggested that the following criteria be used in the evaluation of VEP recordings: latency as well as the difference between latencies and amplitudes of the two sides of the major positive component (P1) as compared with standardized values for ethnic, sex and age groups.