Doctoral Degrees (Obstetrics and Gynaecology)

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The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance
(Stellenbosch : Stellenbosch University, 2002-12) Oehninger, Sergio C.; Franken, D. R.; Stellenbosch University. Faculty of Medicine & Health Sciences . Dept. of Obstetrics & Gynaecology.
ENGLISH ABSTRACT: Infertility is a very common problem worldwide. Recent data have shown that disorders of the male represent the most common single defined cause of infertility. This proposal examines the clinical significance and fundamental physiological aspects of human gamete interaction. These studies are focused on the assessment of the cellular-molecular mechanisms involved in human sperm binding to its homologous zona pellucida resulting in the physiologic induction of the acrosome reaction. We have developed and validated in vitro bioassays that assess specific steps of the fertilization process that are critical for early embryo development. The results of our translational research have already had a significant impact on the overall evaluation of male infertility and on the clinical management of the infertile man in the assisted reproduction arena. Furthermore, the unveiling of the basic mechanisms involved in human gamete interaction will ultimately allow for both (i) the development of new male reproductive diagnostic capabilities and (ii) the design of improved and safer therapies aiding conception in childless couples suffering from male infertility.