Research Articles (Physiological Sciences)
Permanent URI for this collection
Browse
Browsing Research Articles (Physiological Sciences) by Author "Benade, Janina"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- ItemThe impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis(MDPI, 2020) Benade, Janina; Sher, Lucien; De Klerk, Sheneez; Deshpande, Gaurang; Bester, Dirk; Marnewick, Jeanine L.; Sieck, Gary; Laher, Ismail; Essop, M. FaadielCardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (~200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Experimental dosages were calculated according to the surface area-to-volume ratio and were equivalent to 125 mL/day (in human terms). A proteomic analysis was performed on isolated liver samples and thereafter, markers of endoplasmic reticulum (ER) stress, antioxidant/oxidant capacity, calcium regulation, and mitochondrial functionality were assessed. These data show that SSB consumption resulted in (a) the induction of mild hepatic ER stress; (b) altered hepatic mitochondrial dynamics; and (c) perturbed calcium handling across mitochondria-associated ER membranes. Despite significant changes in markers of ER stress, the antioxidant response and calcium handling (proteomics data), the liver is able to initiate adaptive responses to counteract such stressors. However, the mitochondrial data showed increased fission and decreased fusion that may put the organism at risk for developing insulin resistance and T2DM in the longer term.
- ItemIntroduction of sugar tax in South Africa : placebo or panacea to curb the onset of cardio-metabolic diseases?(South African Heart Association, 2017) Benade, Janina; Essop, M. FaaidielDuring 2016 an announcement was made that South Africans will be obliged to pay a 20% “sugar tax’’ that will soon be implemented in order to help curb the rising prevalence of cardio-metabolic diseases. This announcement was met with mixed responses, with strong support from some quarters while others questioned whether it would indeed lead to improved health and well-being of South Africans. As sugar-sweetened beverages (SSBs) constitute a significant portion of added sugars in modern-day diets, it is firmly in the cross-hairs of the new taxation. This perspective article reflects on the proposed sugar tax by exploring the nature of SSB consumption patterns, evaluating epidemiological evidence associating SSB intake to cardio-metabolic diseases risk and by considering examples where a similar tax had previously been introduced. Here data reveal that there is robust evidence supporting a detrimental link between high SSB consumption patterns and the onset of cardiometabolic diseases. It is therefore our strong opinion that the sugar tax option should be pursued in parallel with well-designed, long-term studies to evaluate whether it decreases SSB intake and lowers the prevalence of cardio-metabolic diseases within the South African context.