Proposed mechanisms for the anabolic steriod-induced increase in myocardial susceptibility to ischaemia/reperfusion injury

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dc.contributor.authorDu Toit, E. F.
dc.contributor.authorRossouw, E.
dc.contributor.authorVan Rooyen, J.
dc.contributor.authorLochner, A.
dc.date.accessioned2012-01-23T14:30:49Z
dc.date.available2012-01-23T14:30:49Z
dc.date.issued2005-02
dc.descriptionThe original publication is available at http://www.cvja.co.za/en_ZA
dc.descriptionIncludes bibliography.
dc.description.abstractAndrogenic anabolic steroids (AAS) are often used by athletes to enhance athletic performance but are strongly associated with detrimental cardiovascular effects including sudden cardiac death. Hypothesis: AAS use increases myocardial susceptibility to ischaemia/reperfusion injury. Methods: Rats were trained (swimming) with or without intramuscular injection of nandrolone laurate (0.375 mg/kg). Untrained rats with or without nandrolone served as controls. Hearts were mounted on the Langendorff perfusion apparatus and mechanical function was measured before and after 20-min normothermic global ischaemia. Myocardial tissue samples were collected for determination of tissue cyclic nucleotide and TNFα concentrations. Results: Anabolic steroids decreased the rate pressure product (RPP) of the exercise-trained rat heart [34 582 ± 1 778 mmHg/min vs 28 868 ± 2 446 mmHg/min for exercise-trained steroid-treated hearts (p < 0.05)]. Reperfusion RPP was lower in both the sedentary, and the exercise-trained, steroid-treated hearts than in their concurrent vehicle-treated controls (18 276 ± 2 026 mmHg/min vs 12 018 ± 1 725 mmHg/min for sedentary steroid-treated hearts and, 21 892 ± 2 912 mmHg vs 12 838 ± 1 536 mmHg/min for exercise-trained steroidtreated hearts). Myocardial TNFα [267.75 ± 44.25 pg/g vs 190.00 ± 15.75 pg/g (p < 0.05)] and cAMP concentrations [406.04 ± 18.41 pmol/g vs 235.6 ± 43.26 pmol/gen_ZA
dc.description.versionPublishers' versionen_ZA
dc.format.extentp. 21-28 : ill.
dc.identifier.citationDu Toit, E.F., Rossouw, E., Van Rooyen, J. & Lochner, A. 2005. Proposed mechanisms for the anabolic steriod-induced increase in myocardial susceptibility to ischaemia/reperfusion injury. Cardiovascular Journal of South Africa, 16(1), 21-28en_ZA
dc.identifier.issn1680-0745 (online)
dc.identifier.issn1995-1892 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/19350
dc.language.isoen_ZAen_ZA
dc.publisherClinics Cardiv Publishingen_ZA
dc.rights.holderCardiovascular Journal of Africa holds the copyrighten_ZA
dc.subjectAnabolic steriodsen_ZA
dc.subjectAthletic performanceen_ZA
dc.subjectCardiovascular effectsen_ZA
dc.subjectCardiovascular diseases -- Mortality
dc.subjectCardiovascular diseases -- Effect of anabolic steroids on
dc.titleProposed mechanisms for the anabolic steriod-induced increase in myocardial susceptibility to ischaemia/reperfusion injuryen_ZA
dc.typeArticleen_ZA
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