Effect of cyclosporine and irradiation on experimental pancreatic allografts in the primate

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dc.contributor.authorDu Toit D.F.
dc.contributor.authorHeydenrych J.J.
dc.contributor.authorSmit B.
dc.contributor.authorZuurmond T.
dc.contributor.authorLouw G.
dc.contributor.authorEls D.
dc.contributor.authorBaker L.
dc.contributor.authorWeideman A.
dc.contributor.authorWolfe-Coote S.
dc.contributor.authorDu Toit L.
dc.contributor.authorDavids H.
dc.contributor.authorGroenewald W.
dc.contributor.authorVan Der Merwe E.
dc.contributor.authorPistorius S.
dc.date.accessioned2011-05-15T16:05:05Z
dc.date.available2011-05-15T16:05:05Z
dc.date.issued1988
dc.description.abstractThe present study assessed the effectiveness of cyclosporine (CSA) and subtotal marrow irradiation (TL1) alone, and CSA in combination with TL1 in a primate segmental pancreatic allotransplantation model. Continuous administration of CSA 25 mg/kg/day and 50 mg/kg/day resulted in mean graft survival of 21.5 days and 24.5 days, respectively. Administration of fractionated TL1 800 rad (8 Gy) and 1,000 rad (10 Gy) alone resulted in mean graft survival of 13.3 days and 14.5 days, respectively. Of 20 animals that received TL1 1,000 rad (10 Gy) and CSA 25 mg/kg/day orally for 5 days then 10 mg/kg/day intramuscularly indefinitely, 3 had graft survival of > 100 days. Likewise, of a group of 15 animals that received TL1 800 rad (8 Gy) and combined indefinite administration of CSA, 6 had graft survival of > 100 days. Although CSA and TL1 administration alone produced modest pancreatic allograft survival, a combination of IL1 (800 or 1,000 rad) and CSA resulted in highly significant segmental pancreatic allograft survival in the primate.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation37
dc.identifier.citation3
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12964
dc.subjectcyclosporin
dc.subjectimmunosuppressive agent
dc.subjectanimal experiment
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectpancreas transplantation
dc.subjectwhole body radiation
dc.subjectAnimal
dc.subjectCyclosporins
dc.subjectFemale
dc.subjectGraft Rejection
dc.subjectGraft Survival
dc.subjectMale
dc.subjectPancreas Transplantation
dc.subjectPapio
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransplantation, Homologous
dc.titleEffect of cyclosporine and irradiation on experimental pancreatic allografts in the primate
dc.typeArticle
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