HbA1c of 6.5% to diagnose Diabetes Mellitus—Does it work for Us?—The Bellville South Africa study
| dc.contributor.author | Zemlin, Annalise E. | |
| dc.contributor.author | Matsha, Tandi E. | |
| dc.contributor.author | Hassan, Mogamat S. | |
| dc.contributor.author | Erasmus, Rajiv T. | |
| dc.date.accessioned | 2012-07-30T12:43:15Z | |
| dc.date.available | 2012-07-30T12:43:15Z | |
| dc.date.issued | 2011-08 | |
| dc.description | The original publication is available at http:/www.plosone.org | en_ZA |
| dc.description | Bibliography | |
| dc.description.abstract | Background: HbA1c has been the gold standard for glycaemic control follow-up for decades. In 2009, a level of 6.5% (48 mmol/mol) was proposed as diagnostic for diabetes. We test this cut-off in our community. Methods: Participants (946) from a community-based study were screened for diabetes using either a fasting blood glucose or oral glucose tolerance test (OFTT). The HbA1c cut-off of 6.5% was tested for each group. A receiver operator characteristic (ROC) curve for both groups was generated to establish an optimal cut-off. Results: Our study included 224 (23.7%) males and 722 (76.3%) females. Using fasting blood glucose alone, 117 (14%) were diagnosed with diabetes 250% had an HbA1c value of $6.5% (48 mmol/mol). Using an OGTT, 147 (18%) were diagnosed with diabetes 246% had an HbA1c value of $6.5% (48 mmol/mol). ROC curves found a level of 6.1% (43 mmol/mol) to be optimal in both groups (AUC 0.85 and 0.82 respectively). The sensitivities were 80% and 75% and the specificities 77% and 78% respectively. Conclusions: A cut off of 6.5% (48 mmol/mol) is a good diagnostic tool with its high specificity; however the low sensitivity limits its use. We found a level of 6.1% (43 mmol/mol) to be optimal. This emphasizes the need for evidenced based values to be established in various population groups. | en_ZA |
| dc.description.sponsorship | National Health Laboratory Services of South Africa | |
| dc.description.sponsorship | University Research Fund of the Cape Peninsula University of Technology | |
| dc.description.version | Publishers' Version | en_ZA |
| dc.format.extent | 4 p. : ill. | |
| dc.identifier.citation | Zemlin, A. E., Matsha, T. E., Hassan, M. S. & Erasmus, R.T. 2011. HbA1c of 6.5% to diagnose Diabetes Mellitus—Does It Work for Us?—The Bellville South Africa Study. PLoS ONE, 6(8), e22558, doi:10.1371/journal.pone.0022558. | en_ZA |
| dc.identifier.issn | 1932-6203 (online) | |
| dc.identifier.other | doi:10.1371/journal.pone.0022558 | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/21882 | |
| dc.language.iso | en_ZA | en_ZA |
| dc.publisher | Public Library of Science (PLOS) | en_ZA |
| dc.rights.holder | Authors retain the copyright | en_ZA |
| dc.subject | Diabetes mellitus -- Effect of HbAlc on | en_ZA |
| dc.subject | Diabetes mellitus -- Diagnosis -- Western Cape -- Bellville -- Case study | en_ZA |
| dc.subject | Glycaemic control | en_ZA |
| dc.subject | Diabetes mellitus -- Treatment -- Western Cape -- Bellville -- Case studies | en_ZA |
| dc.subject.lcsh | Medical laboratory diagnosis | en_ZA |
| dc.title | HbA1c of 6.5% to diagnose Diabetes Mellitus—Does it work for Us?—The Bellville South Africa study | en_ZA |
| dc.type | Article | en_ZA |