Viral vaccination and allergy

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dc.contributor.authorKling S.
dc.date.accessioned2011-05-15T16:16:10Z
dc.date.available2011-05-15T16:16:10Z
dc.date.issued2009
dc.description.abstractChildhood immunisation is one of the greatest public health successes of the last century. Adverse vaccine reactions are uncommon and may be caused by the vaccine itself, by preservatives, adjuvants and stabilisers, or by contaminants acquired during the manufacturing process or administration of the vaccine. Influenza vaccine contains significant amounts of egg protein and may cause allergic reactions in egg-sensitive individuals. Adverse reactions are classified as IgE-mediated, delayed hypersensitivity reactions, or non-allergic, manifesting as pyrexia and local reactions. The history is vital in the assessment of an adverse vaccine reaction, particularly in respect of the onset of symptoms in relation to the administration of the vaccine. Skin-prick testing and intradermal testing are useful in assessing IgE-mediated reactions where future vaccination is required. The overwhelming evidence is that childhood immunisations are not causally related to asthma and allergic disease, and are safe. Influenza vaccination is recommended in asthmatics and is safe, but the evidence for its efficacy in preventing asthma exacerbations is not convincing, and it has not been shown to be cost-effective. Parents should be encouraged to have their children immunised against childhood diseases as the benefits far outweigh the risks.
dc.description.versionReview
dc.identifier.citationCurrent Allergy and Clinical Immunology
dc.identifier.citation22
dc.identifier.citation4
dc.identifier.issn16093607
dc.identifier.urihttp://hdl.handle.net/10019.1/13664
dc.subjectaluminum
dc.subjectBCG vaccine
dc.subjectchickenpox vaccine
dc.subjectdrug preservative
dc.subjectegg protein
dc.subjectgelatin
dc.subjecthepatitis A vaccine
dc.subjecthepatitis B vaccine
dc.subjectHLA DR antigen
dc.subjectHLA DR9 antigen
dc.subjectimmunoglobulin E
dc.subjectimmunological adjuvant
dc.subjectinfluenza vaccine
dc.subjectmeasles mumps rubella vaccine
dc.subjectmeasles vaccine
dc.subjectneomycin
dc.subjectovalbumin
dc.subjectovomucoid
dc.subjectpertussis vaccine
dc.subjectthiomersal
dc.subjecttick borne encephalitis vaccine
dc.subjectunclassified drug
dc.subjectvirus vaccine
dc.subjectallergic disease
dc.subjectallergy
dc.subjectallergy test
dc.subjectanaphylaxis
dc.subjectasthma
dc.subjectatopy
dc.subjectchild
dc.subjectclinical trial
dc.subjectcost effectiveness analysis
dc.subjectdelayed hypersensitivity
dc.subjectdisease exacerbation
dc.subjectdisease predisposition
dc.subjectdrug contamination
dc.subjectdrug efficacy
dc.subjectdrug eruption
dc.subjectdrug exposure
dc.subjectdrug hypersensitivity
dc.subjectdrug safety
dc.subjectegg
dc.subjectfever
dc.subjecthuman
dc.subjectimmunization
dc.subjectmeasles vaccination
dc.subjectrash
dc.subjectreview
dc.subjectrisk benefit analysis
dc.subjectserology
dc.subjectvaccination
dc.subjectvirus infection
dc.subjectyeast
dc.titleViral vaccination and allergy
dc.typeReview
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